(2R)-2-amino-4-{4-[(1Z)-{[(3S)-1-[(S)-carboxy(4-hydroxyphenyl)methyl]-2-oxoazetidin-3-yl]carbamoyl}(hydroxyimino)methyl]phenoxy}butanoic acid

• ChemBase ID: 175462
• Molecular Formular: C23H24N4O9
• Molecular Mass: 500.45806
• Monoisotopic Mass: 500.15432837
• SMILES: c1(ccc(cc1)/C(=N/O)/C(=O)N[C@H]1CN(C1=O)[C@@H](c1ccc(cc1)O)C(=O)O)OCC[C@@H](N)C(=O)O
• Canonical SMILES: O/N=C(/c1ccc(cc1)OCC[C@H](C(=O)O)N)\C(=O)N[C@H]1CN(C1=O)[C@@H](c1ccc(cc1)O)C(=O)O
• InChI: InChI=1S/C23H24N4O9/c24-16(22(31)32)9-10-36-15-7-3-12(4-8-15)18(26-35)20(29)25-17-11-27(21(17)30)19(23(33)34)13-1-5-14(28)6-2-13/h1-8,16-17,19,28,35H,9-11,24H2,(H,25,29)(H,31,32)(H,33,34)/b26-18-/t16-,17+,19+/m1/s1
• InChIKey: CTNZOGJNVIFEBA-VYVIOFIUSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: (2R)-2-amino-4-{4-[(1Z)-{[(3S)-1-[(S)-carboxy(4-hydroxyphenyl)methyl]-2-oxoazetidin-3-yl]carbamoyl}(hydroxyimino)methyl]phenoxy}butanoic acid
• IUPAC Traditional name: (2R)-2-amino-4-{4-[(1Z)-{[(3S)-1-[(S)-carboxy(4-hydroxyphenyl)methyl]-2-oxoazetidin-3-yl]carbamoyl}(hydroxyimino)methyl]phenoxy}butanoic acid
• Synonyms: (αR,3S)-3-[[(2Z)-2-[4-[(3R)-3-Amino-3-carboxypropoxy]phenyl]-2-(hydroxyimino)acetyl]amino]-α-(4-hydroxyphenyl)-2-oxo-1-azetidineacetic Acid; Nocardicin A

Database IDs

• CAS Number: 39391-39-4
• PubChem SID: 164231372
• PubChem CID: 71751131

CALCULATED PROPERTIES

• Acid pKa: 1.7427144
• H Acceptors: 11
• H Donor: 6
• LogD (pH = 5.5): -4.735509
• LogD (pH = 7.4): -6.9160576
• Log P: -2.4572067
• Molar Refractivity: 121.8045 cm^3
• Polarizability: 47.32011 Å^3
• Polar Surface Area: 212.08 Å^2
• Rotatable Bonds: 11
• Lipinski's Rule of Five: false

DETAILS

Toronto Research Chemicals - N634000

Nocardicin A is a β-lactam antibiotic.

REFERENCES

• Mendez, R., et al.: Chem. Pharm. Bull., 40, 3222 (1992)
• Reeve, A., et al.: J. Biol. Chem., 273, 30695 (1992)