NAMES AND DATABASE IDS
NAMES AND DATABASE IDS
Names Database IDs
IUPAC name
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4-(4-chlorophenyl)-1-[3-(dimethylcarbamoyl)-3,3-diphenylpropyl]-4-hydroxypiperidin-1-ium-1-olate
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IUPAC Traditional name
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4-(4-chlorophenyl)-1-[3-(dimethylcarbamoyl)-3,3-diphenylpropyl]-4-hydroxypiperidin-1-ium-1-olate
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Synonyms
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trans-4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutanamide 1-Oxide
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Arestal
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Loperamide Oxide
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R 58425
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Loperamide N-Oxide
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CAS Number
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PubChem SID
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PubChem CID
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DATA SOURCES
DATA SOURCES
All Sources Commercial Sources Non-commercial Sources
Data Source
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Data ID
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Price
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TRC
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CALCULATED PROPERTIES
CALCULATED PROPERTIES
JChem
Acid pKa
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13.929086
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H Acceptors
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3
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H Donor
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1
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LogD (pH = 5.5)
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3.6466148
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LogD (pH = 7.4)
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3.646813
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Log P
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3.6468158
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Molar Refractivity
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141.3639 cm3
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Polarizability
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54.379242 Å3
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Polar Surface Area
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67.42 Å2
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Rotatable Bonds
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7
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Lipinski's Rule of Five
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true
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PROPERTIES
PROPERTIES
Safety Information
Product Information
Bioassay(PubChem)
DETAILS
DETAILS
TRC
Toronto Research Chemicals -
L469460
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Loperamide oxide (LOPOX) is a prodrug of Loperamide (LOP). It is concluded that Loperamide oxide administered intraluminally is reduced to Loperamide and has the same antisecretory potency as Loperamide in jejunum and colon. |
REFERENCES
REFERENCES
From Suppliers
Google Scholar
PubMed
Google Books
- • Lavrijsen, K., et al.: Drug Metab. Dispos., 23, 354 (1995)
- • Hesselink, D., et al.: Clin. Pharmacol. Ther., 74, 245 (1995)
- • Hooijberg, J., et al.: Biochem. Pharmacol., 67, 1541 (1995)
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PATENTS
PATENTS
PubChem Patent
Google Patent