N-methyl-N-{3-[3-(thiophene-2-carbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl}acetamide

• ChemBase ID: 171592
• Molecular Formular: C20H16N4O2S
• Molecular Mass: 376.43164
• Monoisotopic Mass: 376.09939677
• SMILES: c1cnc2n(c1c1cccc(c1)N(C)C(=O)C)ncc2C(=O)c1cccs1
• Canonical SMILES: CC(=O)N(c1cccc(c1)c1ccnc2n1ncc2C(=O)c1cccs1)C
• InChI: InChI=1S/C20H16N4O2S/c1-13(25)23(2)15-6-3-5-14(11-15)17-8-9-21-20-16(12-22-24(17)20)19(26)18-7-4-10-27-18/h3-12H,1-2H3
• InChIKey: CBIAWPMZSFFRGN-UHFFFAOYSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: N-methyl-N-{3-[3-(thiophene-2-carbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl}acetamide
• IUPAC Traditional name: indiplon
• Synonyms: N-Methyl-N-[3-[3-[2-thienylcarbonyl]pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]acetamide; NBI 34060; Indiplon

Database IDs

• CAS Number: 325715-02-4
• PubChem SID: 164227502
• PubChem CID: 6450813

CALCULATED PROPERTIES

• H Acceptors: 4
• H Donor: 0
• LogD (pH = 5.5): 2.694206
• LogD (pH = 7.4): 2.6942098
• Log P: 2.69421
• Molar Refractivity: 114.2316 cm^3
• Polarizability: 40.37364 Å^3
• Polar Surface Area: 67.57 Å^2
• Rotatable Bonds: 4
• Lipinski's Rule of Five: true

DETAILS

Toronto Research Chemicals - I527200

Sedative, hypnotic

REFERENCES

• Wegner, F., et al.: J. Neurochem., 107, 1056 (2008)
• McDonald, L., ewt al.: Psychopharmacol., 197, 591 (2008)
• Wegner, F., et al.: Eur. J. Pharmacol., 580, 1 (2008)