2-{4-[(1R)-1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyl]phenyl}-2-methylpropanoic acid

• ChemBase ID: 168952
• Molecular Formular: C32H39NO4
• Molecular Mass: 501.65636
• Monoisotopic Mass: 501.28790873
• SMILES: c1c(ccc(c1)[C@H](O)CCCN1CCC(CC1)C(O)(c1ccccc1)c1ccccc1)C(C)(C)C(=O)O
• Canonical SMILES: OC(=O)C(c1ccc(cc1)[C@@H](CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C
• InChI: InChI=1S/C32H39NO4/c1-31(2,30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,26-10-5-3-6-11-26)27-12-7-4-8-13-27/h3-8,10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36)/t29-/m1/s1
• InChIKey: RWTNPBWLLIMQHL-GDLZYMKVSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: 2-{4-[(1R)-1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyl]phenyl}-2-methylpropanoic acid
• IUPAC Traditional name: fexofenadine hydrochloride
• Synonyms: 4-[(1R)-1-Hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl-benzeneacetic Acid; R-Carboxyterfenadine; R-Terfenadinecarboxylate; (R)-Fexofenadine

Database IDs

• CAS Number: 139965-10-9
• PubChem SID: 162263084
• PubChem CID: 9870655

CALCULATED PROPERTIES

• Acid pKa: 4.040438
• H Acceptors: 5
• H Donor: 3
• LogD (pH = 5.5): 2.9300497
• LogD (pH = 7.4): 2.9334483
• Log P: 2.938501
• Molar Refractivity: 147.9846 cm^3
• Polarizability: 57.84285 Å^3
• Polar Surface Area: 81.0 Å^2
• Rotatable Bonds: 10
• Lipinski's Rule of Five: false

PROPERTIES

Physical Property

• Solubility: Chloroform; Methanol
• Apperance: White to Off-White Solid
• Melting Point: 202-204°C

Safety Information

• Storage Condition: Refrigerator, Under Inert Atmosphere

DETAILS

Toronto Research Chemicals - F322460

The active metabolite of Terfenadine (T114500), a H1-histamine receptor antagonist.

REFERENCES

• Garteiz, D.A., et al.: Arzneim.-Forsch., 32, 1185 (1982)
• Rampe, D., et al.: Mol. Pharmacol., 44, 1240 (1982)
• Obradovic, T., et al.: Pharm. Res., 24, 318 (1982)