2-butyl-4-chloro-1-({4-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-imidazole-5-carboxylic acid

• ChemBase ID: 168838
• Molecular Formular: C22H21ClN6O2
• Molecular Mass: 436.89414
• Monoisotopic Mass: 436.14145162
• SMILES: n1c(c(n(c1CCCC)Cc1ccc(cc1)c1c(cccc1)c1nnn[nH]1)C(=O)O)Cl
• Canonical SMILES: CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)O)Cl
• InChI: InChI=1S/C22H21ClN6O2/c1-2-3-8-18-24-20(23)19(22(30)31)29(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)21-25-27-28-26-21/h4-7,9-12H,2-3,8,13H2,1H3,(H,30,31)(H,25,26,27,28)
• InChIKey: ZEUXAIYYDDCIRX-UHFFFAOYSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: 2-butyl-4-chloro-1-({4-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-imidazole-5-carboxylic acid; 2-butyl-4-chloro-1-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-imidazole-5-carboxylic acid
• IUPAC Traditional name: 2-butyl-5-chloro-3-({4-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)imidazole-4-carboxylic acid; 2-butyl-5-chloro-3-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)imidazole-4-carboxylic acid
• Synonyms: 2-Butyl-4-chloro-1-[[2’-(1H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid; EXP 3174; Losartan Carboxylic AcidNEW CATALOGUE NUMBER: see product L470510; Losartan Carboxylic Acid

Database IDs

• CAS Number: 124750-92-1
• PubChem SID: 162262970
• PubChem CID: 108185

CALCULATED PROPERTIES

• Acid pKa: 2.1697173
• H Acceptors: 6
• H Donor: 2
• LogD (pH = 5.5): 3.155147
• LogD (pH = 7.4): 1.6387428
• Log P: 4.926172
• Molar Refractivity: 132.2899 cm^3
• Polarizability: 46.355473 Å^3
• Polar Surface Area: 109.58 Å^2
• Rotatable Bonds: 8
• Lipinski's Rule of Five: true

PROPERTIES

Physical Property

• Solubility: Dimethyl Sulfoxide; Dimethylformamide; DMF; DMSO; Methanol
• Apperance: Light-Yellow Solid; Off-White to Yellow Solid
• Melting Point: 130-132°C

Safety Information

• Storage Condition: -20°C Freezer

DETAILS

Toronto Research Chemicals - L470510

A metabolite of Losartan.

Toronto Research Chemicals - E960000

A metabolite of Losartan.

REFERENCES

• Pieter, B.M.W.M., et al.: Hypertension, Supp. III, 18, 5, (1991)
• Chang, L.L., et al.: J. Med. Chem., 36, 2558 (1993)
• Pieter, B.M.W.M., et al.: Hypertension, Supp. III, 18, 5, (1991)
• Chang, L.L., et al.: J. Med. Chem., 36, 2558 (1993)