methyl[3-(naphthalen-1-yloxy)-1-phenylpropyl]amine

• ChemBase ID: 165749
• Molecular Formular: C20H21NO
• Molecular Mass: 291.38684
• Monoisotopic Mass: 291.1623143
• SMILES: c1ccc2c(c1)c(ccc2)OCCC(c1ccccc1)NC
• Canonical SMILES: CNC(c1ccccc1)CCOc1cccc2c1cccc2
• InChI: InChI=1S/C20H21NO/c1-21-19(17-9-3-2-4-10-17)14-15-22-20-13-7-11-16-8-5-6-12-18(16)20/h2-13,19,21H,14-15H2,1H3
• InChIKey: SCPPXXMPTQHFGC-UHFFFAOYSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: methyl[3-(naphthalen-1-yloxy)-1-phenylpropyl]amine
• IUPAC Traditional name: methyl[3-(naphthalen-1-yloxy)-1-phenylpropyl]amine
• Synonyms: N-Methyl-α-[2-(1-naphthalenyloxy)ethyl]benzenemethanamine; rac N-Demethyl Dapoxetine

Database IDs

• CAS Number: 119357-18-5
• PubChem SID: 162259882
• PubChem CID: 11779061

CALCULATED PROPERTIES

• H Acceptors: 2
• H Donor: 1
• LogD (pH = 5.5): 1.1089605
• LogD (pH = 7.4): 2.1880126
• Log P: 4.2848477
• Molar Refractivity: 90.844 cm^3
• Polarizability: 37.164005 Å^3
• Polar Surface Area: 21.26 Å^2
• Rotatable Bonds: 6
• Lipinski's Rule of Five: true

DETAILS

Toronto Research Chemicals - D230890

The racemic metabolite of Dapoxetine (D185700). Selective serotonin reuptake inhibitor antidepressant.

REFERENCES

• Wong, D., et al.: Life Sci., 57, 411 (1995)
• Sorbera, L., et al.: Drugs Future, 29, 1201 (1995)
• Cipriani, A., et al.: Lancet, 373, 746 (1995)
• Katzman, M., et al.: CNS Drug, 23, 103 (1995)