sodium (2S,3S,4S,5R,6R)-6-{[(2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methoxy}-3,4,5-trihydroxyoxane-2-carboxylate

• ChemBase ID: 161005
• Molecular Formular: C16H20N5NaO10
• Molecular Mass: 465.34727
• Monoisotopic Mass: 465.11078615
• SMILES: [nH]1c(=O)c(cn(c1=O)[C@H]1C[C@@H]([C@H](O1)CO[C@@H]1O[C@H]([C@H]([C@@H]([C@@H]1O)O)O)C(=O)[O-])N=[N+]=[N-])C.[Na+]
• Canonical SMILES: [N-]=[N+]=N[C@H]1C[C@@H](O[C@@H]1CO[C@@H]1O[C@@H](C(=O)[O-])[C@H]([C@@H]([C@@H]1O)O)O)n1cc(C)c(=O)[nH]c1=O.[Na+]
• InChI: InChI=1S/C16H21N5O10.Na/c1-5-3-21(16(28)18-13(5)25)8-2-6(19-20-17)7(30-8)4-29-15-11(24)9(22)10(23)12(31-15)14(26)27;/h3,6-12,15,22-24H,2,4H2,1H3,(H,26,27)(H,18,25,28);/q;+1/p-1/t6-,7+,8+,9-,10-,11+,12-,15+;/m0./s1
• InChIKey: ANFPIJBVCFGZOF-UACHAAAFSA-M

NAMES AND DATABASE IDS

Names

• IUPAC name: sodium (2S,3S,4S,5R,6R)-6-{[(2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methoxy}-3,4,5-trihydroxyoxane-2-carboxylate
• IUPAC Traditional name: sodium (2S,3S,4S,5R,6R)-6-{[(2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3H-pyrimidin-1-yl)oxolan-2-yl]methoxy}-3,4,5-trihydroxyoxane-2-carboxylate
• Synonyms: 3'-Azido-3'-deoxy-5'-O-β-D-glucopyranuronosyl-thymidine Monosodium Salt; AZT Glucuronide Sodium Salt; Zidovudine Glucuronide Sodium Salt; 3'-Azido-3'-deoxythymidine β-D-glucuronide, Sodium Salt

Database IDs

• CAS Number: 133525-01-6
• PubChem SID: 162255140
• PubChem CID: 71313575

CALCULATED PROPERTIES

• Acid pKa: 3.2377744
• H Acceptors: 12
• H Donor: 4
• LogD (pH = 5.5): -4.105065
• LogD (pH = 7.4): -5.303058
• Log P: -1.7492703
• Molar Refractivity: 104.8223 cm^3
• Polarizability: 37.40936 Å^3
• Polar Surface Area: 207.35 Å^2
• Rotatable Bonds: 6
• Lipinski's Rule of Five: false

PROPERTIES

Physical Property

• Solubility: DMSO; Water
• Apperance: Off-White Solid
• Melting Point: >200°C (dec.)

Safety Information

• Storage Condition: -20°C Freezer, Under Inert Atmosphere

DETAILS

Toronto Research Chemicals - A825050

A metabolite of the potent and selective inhibitor of HIV-1 replication, AZT.