NAMES AND DATABASE IDS
NAMES AND DATABASE IDS
Names Database IDs
IUPAC name
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N-[dihydroxy(2H5)propyl]-3-[(2-fluoro-4-iodophenyl)amino]pyridine-4-carboxamide
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IUPAC Traditional name
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N-[dihydroxy(2H5)propyl]-3-[(2-fluoro-4-iodophenyl)amino]pyridine-4-carboxamide
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Synonyms
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N-[(2R,S)-2,3-Dihydroxypropyl-d5]-3-[(2-fluoro-4-iodophenyl)amino]-4-pyridinecarboxamide
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rac-AS-703026-d5
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DATA SOURCES
DATA SOURCES
All Sources Commercial Sources Non-commercial Sources
Data Source
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Data ID
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Price
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TRC
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CALCULATED PROPERTIES
CALCULATED PROPERTIES
JChem
Acid pKa
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13.665774
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H Acceptors
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5
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H Donor
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4
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LogD (pH = 5.5)
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2.3146443
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LogD (pH = 7.4)
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2.3209436
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Log P
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2.321025
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Molar Refractivity
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92.1961 cm3
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Polarizability
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34.81543 Å3
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Polar Surface Area
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94.48 Å2
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Rotatable Bonds
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6
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Lipinski's Rule of Five
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true
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PROPERTIES
PROPERTIES
Safety Information
Product Information
Bioassay(PubChem)
DETAILS
DETAILS
TRC
Toronto Research Chemicals -
A780102
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Labelled AS703026 (A780100). AS703026 is a novel, selective, orally bioavailable MEK1/2 inhibitor, in human multiple myeloma (MM). AS703026 induces pleiotropic anti-myeloma activity in vitro and in vivo. MEK inhibitors are useful in the treatment of hyper |
REFERENCES
REFERENCES
From Suppliers
Google Scholar
PubMed
Google Books
- • Billadeau, D., et al.: Cancer Res., 55, 3640 (1995)
- • Kolch, W., et al.: Biochem. J., 351, 289 (1995)
- • Smith, M., et al.: Leukemia, 17, 274 (1995)
- • Adjei, A., et al.: J. Clin. Oncol., 26, 2139 (1995)
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PATENTS
PATENTS
PubChem Patent
Google Patent