N-methyl-N-(trimethylsilyl)acetamide

• ChemBase ID: 158202
• Molecular Formular: C6H15NOSi
• Molecular Mass: 145.2749
• Monoisotopic Mass: 145.09229064
• SMILES: CC(=O)N(C)[Si](C)(C)C
• Canonical SMILES: CC(=O)N([Si](C)(C)C)C
• InChI: InChI=1S/C6H15NOSi/c1-6(8)7(2)9(3,4)5/h1-5H3
• InChIKey: QHUOBLDKFGCVCG-UHFFFAOYSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: N-methyl-N-(trimethylsilyl)acetamide
• IUPAC Traditional name: N-methyl-N-(trimethylsilyl)acetamide
• Synonyms: MSA; N-Methyl-N-trimethylsilylacetamide; N-Trimethylsilyl-N-methylacetamide; N-甲基-N-三甲基硅烷乙酰胺

Database IDs

• CAS Number: 7449-74-3
• EC Number: 231-217-0
• MDL Number: MFCD00040758
• Beilstein Number: 506975
• PubChem SID: 162252338; 24885933
• PubChem CID: 81953

CALCULATED PROPERTIES

• H Acceptors: 1
• H Donor: 0
• LogD (pH = 5.5): 0.9180999
• LogD (pH = 7.4): 0.9181
• Log P: 0.9181
• Molar Refractivity: 35.9029 cm^3
• Polarizability: 15.926127 Å^3
• Polar Surface Area: 20.31 Å^2
• Rotatable Bonds: 1
• Lipinski's Rule of Five: true

PROPERTIES

Physical Property

• Boiling Point: 159-161 °C(lit.); 48-49°C/11mm
• Flash Point: 118.4 °F; 48 °C; 48°C(118°F)
• Density: 0.904 g/mL at 20 °C(lit.); 0.906
• Refractive Index: 1.4390; n20/D 1.439

Safety Information

• Storage Warning: Moisture Sensitive
• European Hazard Symbols: Irritant (Xi)
• UN Number: 1993; UN1993
• German water hazard class: 3
• Hazard Class: 3
• Packing Group: 3; III
• Risk Statements: 10; 10-36/37/38
• Safety Statements: 23-26-37
• TSCA Listed: 是
• GHS Pictograms: GHS02; GHS07
• GHS Signal Word: Warning
• GHS Hazard statements: H226; H226-H315-H319-H335
• GHS Precautionary statements: P210-P241-P303+P361+P353-P305+P351+P338-P405-P501A
• Personal Protective Equipment: Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• RID/ADR: UN 1993 3/PG 3
• Storage Temperature: -20°C

Product Information

• Purity: ≥97.0% (GC); 98%
• Grade: for GC derivatization
• Empirical Formula (Hill Notation): C6H15NOSi

DETAILS

Sigma Aldrich - 69480

Other Notes
Powerful silylating agent for polar compounds1,2

REFERENCES

• Silylating agent, compare N,O-Bis(trimethylsilyl)acetamide, L00183.