NAMES AND DATABASE IDS
NAMES AND DATABASE IDS
Names Database IDs
IUPAC name
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1,4-bis({[2-(dimethylamino)ethyl]amino})-5,8-dihydroxy-9,10-dihydroanthracene-9,10-dione
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IUPAC Traditional name
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1,4-bis({[2-(dimethylamino)ethyl]amino})-5,8-dihydroxyanthracene-9,10-dione
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Synonyms
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1,4-Bis[[2-(dimethylamino)ethyl]amino]-5,8-dihydroxy-9,10-anthracenedione
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1,4-Bis[[2-(dimethylamino)ethyl]amino]-5,8-dihydroxyanthracene-9,10-dione
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AQ4
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CAS Number
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MDL Number
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PubChem SID
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PubChem CID
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DATA SOURCES
DATA SOURCES
All Sources Commercial Sources Non-commercial Sources
CALCULATED PROPERTIES
CALCULATED PROPERTIES
JChem
Acid pKa
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9.659531
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H Acceptors
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8
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H Donor
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4
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LogD (pH = 5.5)
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-0.07586288
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LogD (pH = 7.4)
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3.191027
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Log P
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3.8944206
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Molar Refractivity
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121.5386 cm3
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Polarizability
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44.5837 Å3
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Polar Surface Area
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105.14 Å2
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Rotatable Bonds
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8
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Lipinski's Rule of Five
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true
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DETAILS
DETAILS
Sigma Aldrich
Sigma Aldrich -
A9236
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Biochem/physiol Actions AQ4 is a chemically stable cytotoxic agent which acts as a topoisomerase II inhibitor and DNA intercalator. The compound is a potent cytotoxic agent in many human tumor lines, including those derived from human pancreatic adenocarcinomas. The compound N-oxide is a hypoxia activated prodrug of topoisomerase-targeting. |
PATENTS
PATENTS
PubChem Patent
Google Patent