NAMES AND DATABASE IDS
NAMES AND DATABASE IDS
Names Database IDs
IUPAC name
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N-(1,3,4-thiadiazol-2-yl)pyridine-3-carboxamide
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IUPAC Traditional name
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N-(1,3,4-thiadiazol-2-yl)pyridine-3-carboxamide
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Synonyms
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2-(Nicotinamide)-1,3,4-thiadiazole
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N-(1,3,4-Thiadiazol-2-yl)-3-pyridinecarboxamide
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N-(1,3,4-Thiadiazol-2-yl)pyridine-3-carboxamide
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N-(1,3,4-Thiadiazolyl)-m-nicotinamide
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TGN-020
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N-(1,3,4-Thiadiazolyl)nicotinamide
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CAS Number
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MDL Number
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PubChem SID
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PubChem CID
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DATA SOURCES
DATA SOURCES
All Sources Commercial Sources Non-commercial Sources
CALCULATED PROPERTIES
CALCULATED PROPERTIES
JChem
Acid pKa
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7.1211987
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H Acceptors
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4
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H Donor
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1
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LogD (pH = 5.5)
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0.29274824
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LogD (pH = 7.4)
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-0.11689633
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Log P
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0.3067543
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Molar Refractivity
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54.2391 cm3
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Polarizability
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19.060316 Å3
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Polar Surface Area
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67.77 Å2
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Rotatable Bonds
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2
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Lipinski's Rule of Five
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true
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DETAILS
DETAILS
Sigma Aldrich
TRC
Sigma Aldrich -
SML0136
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Biochem/physiol Actions TGN-020 is an inhibitor of Aquaporin 4 (AQP4), the most abundant water channel in brain. Aquaporins (AQPs) are water channels required for maintaining fluid homeostasis and enabling water movement across barrier membranes, but can enhance pathological cellular volume changes and cause edema in injury states. Pretreatment with the AQP4 inhibitor TGN-020 significantly reduced the volume of brain edema associated with ischemic injury in a mouse model of focal cerebral ischemia. |
REFERENCES
REFERENCES
From Suppliers
Google Scholar
PubMed
Google Books
- • Papadopoulos, M., et al.: J. Biol. Chem., 280, 13906 (2005)
- • Gao, J., et al.: Anal. Biochem., 350, 165 (2005)
- • Huber, V., et al.: Bioorg. Med. Chem., 17, 418 (2005)
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PATENTS
PATENTS
PubChem Patent
Google Patent