N-(prop-2-enamidomethyl)prop-2-enamide; prop-2-enamide

• ChemBase ID: 153228
• Molecular Formular: C10H15N3O3
• Molecular Mass: 225.2444
• Monoisotopic Mass: 225.11134136
• SMILES: C=CC(=O)N.C=CC(=O)NCNC(=O)C=C
• Canonical SMILES: C=CC(=O)NCNC(=O)C=C.C=CC(=O)N
• InChI: InChI=1S/C7H10N2O2.C3H5NO/c1-3-6(10)8-5-9-7(11)4-2;1-2-3(4)5/h3-4H,1-2,5H2,(H,8,10)(H,9,11);2H,1H2,(H2,4,5)
• InChIKey: OCQZXMCGTAWGEQ-UHFFFAOYSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: N-(prop-2-enamidomethyl)prop-2-enamide; prop-2-enamide
• IUPAC Traditional name: N,N'-methylenebisacrylamide; acrylamide
• Synonyms: Acrylamide:N,N′-Methylenebisacrylamide 19:1; Agarose ME, for electrophoresis of macromolecules; Acrylamide/bis-acrylamide, 40% solution; Acrylamide/Bis-acrylamide, 30% solution; Acrylamide/Bis-acrylamide; 丙烯酰胺:N,N′-亚甲基双丙烯酰胺 19:1; 琼脂糖ME,用作大分子电泳

Database IDs

• CAS Number: 9012-36-6
• EC Number: 232-731-8
• MDL Number: MFCD00080848; MFCD00081294
• PubChem SID: 162247367
• PubChem CID: 168241

CALCULATED PROPERTIES

• Acid pKa: 13.675445
• H Acceptors: 2
• H Donor: 2
• LogD (pH = 5.5): -0.16206302
• LogD (pH = 7.4): -0.16206253
• Log P: -0.16206251
• Molar Refractivity: 40.8611 cm^3
• Polarizability: 15.584384 Å^3
• Polar Surface Area: 58.2 Å^2
• Rotatable Bonds: 5
• Lipinski's Rule of Five: true

PROPERTIES

Physical Property

• Solubility: H2O: soluble50 mg/mL at 20 °C, clear, colorless
• Conductivity: <20 μS/cm at 20 °C (50 mg/ml water)

Safety Information

• European Hazard Symbols: Toxic (T)
• UN Number: 2074; 3426
• German water hazard class: 3
• Hazard Class: 6.1
• Packing Group: 3
• Risk Statements: 45-46-20/21-25-36/38-43-48/23/24/25-62
• Safety Statements: 53-26-36/37-45
• TSCA Listed: 是
• GHS Pictograms: GHS06; GHS08
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H312-H315-H317-H319-H332-H340-H350-H361f-H372; H301-H315-H317-H319-H330-H334-H340-H350-H361f-H372; H301-H315-H317-H319-H330-H340-H350-H361f-H372
• GHS Precautionary statements: P201-P260-P280-P284-P301 + P310-P305 + P351 + P338; P201-P280-P301 + P310-P305 + P351 + P338-P308 + P313
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges; Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter; Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• RID/ADR: UN 2074 6.1/PG 3; UN 3426 6.1/PG 3
• Storage Temperature: 2-8°C

Product Information

• Grade: for molecular biology
• Suitability: in accordance for electrophoresis test; suitable for electrophoresis
• Impurities: DNases, none detected; phosphatases, none detected; proteases, none detected; RNases, none detected
• Cation Traces: Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Zn: ≤5 mg/kg
• Antion Traces: chloride (Cl-): ≤50 mg/kg; sulfate (SO42-): ≤50 mg/kg
• Foreign Activity: DNAse (exonuclease), NICKase (endonuclease), RNAse, and protease, none detected; DNase (Exonuclease), NICKase (Endonuclease), RNase, protease, none detected; DNase, RNase and protease, none detected
• Sterility: 0.2 μm filtered
• Feed ratio: 19:1; 19:1 (ratio); 29:1; 29:1 (ratio); 37.5:1; 37:1 (ratio); 49:1 (ratio)
• Product Line: BioReagent

DETAILS

Sigma Aldrich - A0924

Application
Ready to reconstitute dry powder blends are accurately pre-blended to produce a 40% (w/v) stock solution for use in protein and nucleic acid electrophoresis. The concentration is based on the total weight of both the acrylamide and bis-acrylamide.
Features and Benefits
Eliminates the need to weigh toxic acrylamide and bis-acrylamide.
Reconstitution
Reconstitute by slowly adding the indicated amount of distilled water to the container and dissolve contents.

Sigma Aldrich - A3449

Application
These 30% (w/v) acrylamide/bis-acrylamide solutions are available at the most common ratios for use in protein and nucleic acid electrophoresis. The concentration is based on the total weight of both the acrylamide and bis-acrylamide.
Preparation Note
Solution prepared from electrophoresis grade acrylamide and bis-acrylamide in ultra-pure water.

Sigma Aldrich - A9926

Application
These acrylamide/bis-acrylamide solutions are available at the most common ratios for use in protein and nucleic acid electrophoresis. The concentration is based on the total weight of both the acrylamide and bis-acrylamide.
Preparation Note
Solution prepared from electrophoresis grade acrylamide and bis-acrylamide in ultra-pure water.

Sigma Aldrich - A7168

Application
These acrylamide/bis-acrylamide solutions are available at the most common ratios for use in protein and nucleic acid electrophoresis. The concentration is based on the total weight of both the acrylamide and bis-acrylamide.
Preparation Note
Solution prepared from electrophoresis grade acrylamide and bis-acrylamide in ultra-pure water.

Sigma Aldrich - A3574

Application
These 30% (w/v) acrylamide/bis-acrylamide solutions are available at the most common ratios for use in protein and nucleic acid electrophoresis. The concentration is based on the total weight of both the acrylamide and bis-acrylamide.
Preparation Note
Solution prepared from electrophoresis grade acrylamide and bis-acrylamide in ultra-pure water.

Sigma Aldrich - A3699

Application
These 30% (w/v) acrylamide/bis-acrylamide solutions are available at the most common ratios for use in protein and nucleic acid electrophoresis. The concentration is based on the total weight of both the acrylamide and bis-acrylamide.
Preparation Note
Solution prepared from electrophoresis grade acrylamide and bis-acrylamide in ultra-pure water.

Sigma Aldrich - 01707

Other Notes
DNA sequencing1

Sigma Aldrich - A2917

Application
Ready to reconstitute dry powder blends are accurately pre-blended to produce a 40% (w/v) stock solution for use in protein and nucleic acid electrophoresis. The concentration is based on the total weight of both the acrylamide and bis-acrylamide.
Features and Benefits
Eliminates the need to weigh toxic acrylamide and bis-acrylamide.
Reconstitution
Reconstitute by slowly adding the indicated amount of distilled water to the container and dissolve contents.

Sigma Aldrich - A7802

Application
These acrylamide/bis-acrylamide solutions are available at the most common ratios for use in protein and nucleic acid electrophoresis. The concentration is based on the total weight of both the acrylamide and bis-acrylamide.
Preparation Note
Solution prepared from electrophoresis grade acrylamide and bis-acrylamide in ultra-pure water.

Sigma Aldrich - A2792

Application
Ready to reconstitute dry powder blends are accurately pre-blended to produce a 40% (w/v) stock solution for use in protein and nucleic acid electrophoresis. The concentration is based on the total weight of both the acrylamide and bis-acrylamide.
Features and Benefits
Eliminates the need to weigh toxic acrylamide and bis-acrylamide.
Reconstitution
Reconstitute by slowly adding the indicated amount of distilled water to the container and dissolve contents.

Sigma Aldrich - A6050

Application
Ready to reconstitute dry powder blends are accurately pre-blended to produce a 40% (w/v) stock solution for use in protein and nucleic acid electrophoresis. The concentration is based on the total weight of both the acrylamide and bis-acrylamide.
Features and Benefits
Eliminates the need to weigh toxic acrylamide and bis-acrylamide.
Reconstitution
A 1 liter bottle of A6050 should be reconstituted with 630 ml of water. A 100 ml bottle should be reconstituted with 63 ml of water.
Reconstitute by slowly adding the indicated amount of distilled water to the container and dissolve contents.