[2-hydroxy-3-(octadeca-9,12-dienoyloxy)propoxy]phosphonic acid

• ChemBase ID: 133713
• Molecular Formular: C21H39O7P
• Molecular Mass: 434.503921
• Monoisotopic Mass: 434.24334022
• SMILES: CCCCC/C=C/C/C=C/CCCCCCCC(=O)OCC(COP(=O)(O)O)O
• Canonical SMILES: CCCCC/C=C/C/C=C/CCCCCCCC(=O)OCC(COP(=O)(O)O)O
• InChI: InChI=1S/C21H39O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h6-7,9-10,20,22H,2-5,8,11-19H2,1H3,(H2,24,25,26)/b7-6+,10-9+
• InChIKey: ZQTAMPRZFOOEEP-AVQMFFATSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: [2-hydroxy-3-(octadeca-9,12-dienoyloxy)propoxy]phosphonic acid; {2-hydroxy-3-[(9E,12E)-octadeca-9,12-dienoyloxy]propoxy}phosphonic acid
• IUPAC Traditional name: 2-hydroxy-3-(octadeca-9,12-dienoyloxy)propoxyphosphonic acid; 2-hydroxy-3-[(9E,12E)-octadeca-9,12-dienoyloxy]propoxyphosphonic acid
• Synonyms: Anti-Platelet-activating factor acetylhydrolase; Anti-Lissencephaly 1; Anti-PAFAH; Anti-LIS1 antibody produced in rabbit; Monoclonal Anti-LIS1 antibody produced in mouse

Database IDs

• MDL Number: MFCD03457563
• PubChem SID: 24896475; 162227990
• PubChem CID: 5795880
• NCBI accession number: P43034

CALCULATED PROPERTIES

• Acid pKa: 1.5053178
• H Acceptors: 5
• H Donor: 3
• LogD (pH = 5.5): 2.7191758
• LogD (pH = 7.4): 1.8368158
• Log P: 5.123768
• Molar Refractivity: 116.4156 cm^3
• Polarizability: 45.21914 Å^3
• Polar Surface Area: 113.29 Å^2
• Rotatable Bonds: 20
• Lipinski's Rule of Five: false

PROPERTIES

Physical Property

• Apperance: buffered aqueous solution

Safety Information

• German water hazard class: -; 3
• Storage Temperature: -20°C

Pharmacology Properties

• Gene Information: human ... PAFAH1B1(5048); human ... PAFAH1B1(5048)mouse ... Pafah1b1(18472)rat ... Pafah1b1(83572)

Product Information

• Concentration: ~2 mg/mL
• Application(s): immunocytochemistry: suitable; immunoprecipitation: suitable; indirect ELISA: suitable; microarray: suitable; western blot: 0.5-1 μg/mL using a rat brain cytosol preparation; western blot: suitable
• Shipped in: dry ice
• Clone: LIS1-338, monoclonal; polyclonal
• Species Reactivity: bovine, chicken, human, rat, mouse, zebrafish; human, mouse, rat
• Antibody Form: affinity isolated antibody; purified immunoglobulin
• Isotype: IgG1
• Mol. Weight: antigen mol wt 46 kDa

DETAILS

Sigma Aldrich - SAB3500302

Immunogen
LIS1 antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human LIS1.
Physical form
Supplied in PBS with 0.02% sodium azide.

Sigma Aldrich - L7391

Immunogen
recombinant human LIS1 protein.
Specificity
By immunoblotting, the antibody prefers the phosphorylated form of the LIS1 molecule (46 kDa).
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.