(4R,7R)-6,11-diazatetracyclo[7.6.1.02,7.012,16]hexadeca-1(16),2,9,12,14-pentaene-4-carboxylic acid

• ChemBase ID: 132961
• Molecular Formular: C15H14N2O2
• Molecular Mass: 254.28386
• Monoisotopic Mass: 254.1055277
• SMILES: c1cc2c3c(c1)[nH]cc3C[C@@H]1C2=C[C@H](CN1)C(=O)O
• Canonical SMILES: OC(=O)[C@H]1CN[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3
• InChI: InChI=1S/C15H14N2O2/c18-15(19)9-4-11-10-2-1-3-12-14(10)8(6-16-12)5-13(11)17-7-9/h1-4,6,9,13,16-17H,5,7H2,(H,18,19)/t9-,13-/m1/s1
• InChIKey: VGLIYJAMHMSYBY-NOZJJQNGSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: (4R,7R)-6,11-diazatetracyclo[7.6.1.0^2,^7.0^1^2,^1^6]hexadeca-1(16),2,9,12,14-pentaene-4-carboxylic acid
• IUPAC Traditional name: (4R,7R)-6,11-diazatetracyclo[7.6.1.0^2,^7.0^1^2,^1^6]hexadeca-1(16),2,9,12,14-pentaene-4-carboxylic acid
• Synonyms: Anti-Nephronophthisis (NPH) (pic) antibody produced in rabbit

Database IDs

• MDL Number: MFCD03455624
• PubChem SID: 24897784; 162227238
• PubChem CID: 16219768

CALCULATED PROPERTIES

• Acid pKa: 3.6392329
• H Acceptors: 3
• H Donor: 3
• LogD (pH = 5.5): -0.9315615
• LogD (pH = 7.4): -0.9287332
• Log P: -0.9275858
• Molar Refractivity: 72.3272 cm^3
• Polarizability: 28.757874 Å^3
• Polar Surface Area: 65.12 Å^2
• Rotatable Bonds: 1
• Lipinski's Rule of Five: true

PROPERTIES

Physical Property

• Apperance: buffered aqueous solution

Safety Information

• German water hazard class: -
• Storage Temperature: -20°C

Pharmacology Properties

• Gene Information: mouse ... Nphp1(53885)

Product Information

• Application(s): immunoprecipitation: 10-20 μg/mL; western blot: 2-10 μg/mL
• Shipped in: dry ice
• Clone: polyclonal
• Species Reactivity: mouse
• Antibody Form: IgG fraction of antiserum
• Mol. Weight: antigen mol wt 90 kDa

DETAILS

Sigma Aldrich - N6523

Immunogen
GST fusion protein corresponding to amino acids 612-691 of mouse NPH.
Physical form
Solution in phosphate buffered saline containing 0.08% sodium azide.