(2S)-6-amino-2-[(2R)-2-[(2S)-2-[(2S)-2-[(2R)-2-[(2S)-2-amino-3-(1H-imidazol-5-yl)propanamido]-3-(1H-indol-3-yl)propanamido]propanamido]-3-(1H-indol-3-yl)propanamido]-3-phenylpropanamido]hexanamide

• ChemBase ID: 132900
• Molecular Formular: C46H56N12O6
• Molecular Mass: 873.01364
• Monoisotopic Mass: 872.44457757
• SMILES: C[C@@H](C(=O)N[C@@H](Cc1c[nH]c2c1cccc2)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N)NC(=O)[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](Cc1cnc[nH]1)N
• Canonical SMILES: NCCCC[C@@H](C(=O)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](Cc1cnc[nH]1)N)C
• InChI: InChI=1S/C46H56N12O6/c1-27(54-44(62)39(20-29-23-51-35-15-7-5-13-32(29)35)57-43(61)34(48)22-31-25-50-26-53-31)42(60)56-40(21-30-24-52-36-16-8-6-14-33(30)36)46(64)58-38(19-28-11-3-2-4-12-28)45(63)55-37(41(49)59)17-9-10-18-47/h2-8,11-16,23-27,34,37-40,51-52H,9-10,17-22,47-48H2,1H3,(H2,49,59)(H,50,53)(H,54,62)(H,55,63)(H,56,60)(H,57,61)(H,58,64)/t27-,34-,37-,38+,39+,40-/m0/s1
• InChIKey: WZHKXNSOCOQYQX-FUAFALNISA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: (2S)-6-amino-2-[(2R)-2-[(2S)-2-[(2S)-2-[(2R)-2-[(2S)-2-amino-3-(1H-imidazol-5-yl)propanamido]-3-(1H-indol-3-yl)propanamido]propanamido]-3-(1H-indol-3-yl)propanamido]-3-phenylpropanamido]hexanamide
• IUPAC Traditional name: (2S)-6-amino-2-[(2R)-2-[(2S)-2-[(2S)-2-[(2R)-2-[(2S)-2-amino-3-(3H-imidazol-4-yl)propanamido]-3-(1H-indol-3-yl)propanamido]propanamido]-3-(1H-indol-3-yl)propanamido]-3-phenylpropanamido]hexanamide
• Synonyms: GHRP-6; [D-Trp7, Ala8, D-Phe10]-α-Melanocyte Stimulating Hormone Amide Fragment 6-11

Database IDs

• CAS Number: 87616-84-0
• MDL Number: MFCD00872694
• PubChem SID: 162227177; 24896777
• PubChem CID: 9919153

CALCULATED PROPERTIES

• Acid pKa: 11.772869
• H Acceptors: 9
• H Donor: 11
• LogD (pH = 5.5): -5.38291
• LogD (pH = 7.4): -2.9301493
• Log P: 0.1955095
• Molar Refractivity: 239.7104 cm^3
• Polarizability: 95.30395 Å^3
• Polar Surface Area: 300.89 Å^2
• Rotatable Bonds: 23
• Lipinski's Rule of Five: false

PROPERTIES

Safety Information

• German water hazard class: 3
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: -20°C

Pharmacology Properties

• Gene Information: human ... POMC(5443)rat ... Ghsr(84022)

Product Information

• Purity: ≥97% (HPLC)

DETAILS

Sigma Aldrich - M2910

Amino Acid Sequence
His-Trp-Ala-Trp-Phe-Lys-NH2
Biochem/physiol Actions
Selective inhibitor of α-MSH activity in frog skin bioassay; identical to (His1,Lys8)-GH which selectively releases growth hormone in vitro and in vivo; somatostatin antagonist.