(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-{[(1S,5R,13R,14S)-14-hydroxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraen-10-yl]oxy}oxane-2-carboxylic acid

• ChemBase ID: 130690
• Molecular Formular: C23H27NO9
• Molecular Mass: 461.46178
• Monoisotopic Mass: 461.16858145
• SMILES: CN1CC[C@]23c4c5ccc(c4O[C@H]2[C@H](C=CC3[C@@H]1C5)O)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)C(=O)O)O)O)O
• Canonical SMILES: O[C@@H]1[C@@H](O)[C@@H](O[C@@H]([C@H]1O)C(=O)O)Oc1ccc2c3c1O[C@@H]1[C@@]43CCN([C@@H](C2)C4C=C[C@@H]1O)C
• InChI: InChI=1S/C23H27NO9/c1-24-7-6-23-10-3-4-12(25)20(23)32-18-13(5-2-9(14(18)23)8-11(10)24)31-22-17(28)15(26)16(27)19(33-22)21(29)30/h2-5,10-12,15-17,19-20,22,25-28H,6-8H2,1H3,(H,29,30)/t10?,11-,12+,15+,16+,17-,19+,20+,22-,23+/m1/s1
• InChIKey: WAEXKFONHRHFBZ-RURUVCMVSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-{[(1S,5R,13R,14S)-14-hydroxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^1,^1^3.0^5,^1^7.0^7,^1^8]octadeca-7(18),8,10,15-tetraen-10-yl]oxy}oxane-2-carboxylic acid
• IUPAC Traditional name: (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-{[(1S,5R,13R,14S)-14-hydroxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^1,^1^3.0^5,^1^7.0^7,^1^8]octadeca-7(18),8,10,15-tetraen-10-yl]oxy}oxane-2-carboxylic acid
• Synonyms: Morphine 3-β-D-glucuronide solution; M3G; Morphine 3-β-D-glucuronide; 吗啡 3-β-D-葡萄糖苷酸 溶液; 吗啡 3-β-D-葡萄糖苷酸

Database IDs

• CAS Number: 20290-09-9
• MDL Number: MFCD00056773
• PubChem SID: 24896814; 24897126; 162224968
• PubChem CID: 16217590

CALCULATED PROPERTIES

• Acid pKa: 2.673982
• H Acceptors: 10
• H Donor: 5
• LogD (pH = 5.5): -3.4821389
• LogD (pH = 7.4): -3.4876406
• Log P: -3.4819388
• Molar Refractivity: 112.1342 cm^3
• Polarizability: 44.3441 Å^3
• Polar Surface Area: 149.15 Å^2
• Rotatable Bonds: 3
• Lipinski's Rule of Five: true

PROPERTIES

Safety Information

• European Hazard Symbols: Toxic (T); Harmful (Xn)
• UN Number: 1230
• German water hazard class: 1; 3
• Hazard Class: 3
• Packing Group: 2
• Risk Statements: 22-43; 23/24/25-39/23/24/25
• Safety Statements: 36/37; 36/37-45
• GHS Pictograms: GHS06; GHS07; GHS08
• GHS Signal Word: Danger; Warning
• GHS Hazard statements: H301-H311-H331-H370; H302-H317
• GHS Precautionary statements: P260-P280-P301 + P310-P311; P280
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves; Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• RID/ADR: UN 1230 3/PG 2
• Drug Control: Home Office Schedule 2; stupéfiant; kontrollierte Droge in Deutschland; USDEA Schedule II; Home Office Schedule 2; stupéfiant; kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada
• Storage Temperature: 2-8°C

Product Information

• Concentration: 1.0 mg/mL±5% in methanol
• Grade: drug standard

DETAILS

Sigma Aldrich - M6886

Biochem/physiol Actions
Metabolite of morphine that is devoid of antinociceptic activity; hyperglycemic and neuroexcitatory effects appear to be mediated via a non-opioid mechanism.