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51-57-0 molecular structure
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methyl[(2S)-1-phenylpropan-2-yl]amine hydrochloride

ChemBase ID: 130689
Molecular Formular: C10H16ClN
Molecular Mass: 185.69374
Monoisotopic Mass: 185.0971272
SMILES and InChIs

SMILES:
C[C@@H](Cc1ccccc1)NC.Cl
Canonical SMILES:
CN[C@H](Cc1ccccc1)C.Cl
InChI:
InChI=1S/C10H15N.ClH/c1-9(11-2)8-10-6-4-3-5-7-10;/h3-7,9,11H,8H2,1-2H3;1H/t9-;/m0./s1
InChIKey:
TWXDDNPPQUTEOV-FVGYRXGTSA-N

Cite this record

CBID:130689 http://www.chembase.cn/molecule-130689.html

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NAMES AND DATABASE IDS

NAMES AND DATABASE IDS

Names Database IDs
IUPAC name
methyl[(2S)-1-phenylpropan-2-yl]amine hydrochloride
IUPAC Traditional name
crank hydrochloride
Synonyms
d-Desoxyephedrine hydrochloride
d-N,α-Dimethylphenethylamine hydrochloride
Methylamphetamine hydrochloride
(+)-Methamphetamine hydrochloride
(+)-Methamphetamine hydrochloride solution
(αS)-N,α-Dimethylbenzeneethanamine Hydrochloride
L-(+)-Methamphetamine Chloride
Adipex
Amphedroxyn
Deofed
Desfedrin
Desoxo 5
Hiropon
Isophen
Madrine
Methedrine
Tonedron
S-(+)-Methamphetamine Hydrochloride
(+)-甲基苯丙胺 盐酸盐
(+)-甲基苯丙胺 盐酸盐 溶液
CAS Number
51-57-0
EC Number
200-106-9
MDL Number
MFCD00056130
PubChem SID
162224967
24897282
24896988
PubChem CID
66124

DATA SOURCES

DATA SOURCES

All Sources Commercial Sources Non-commercial Sources
Data Source Data ID
PubChem 66124 external link

CALCULATED PROPERTIES

CALCULATED PROPERTIES

JChem
H Acceptors H Donor
LogD (pH = 5.5) -0.9906569  LogD (pH = 7.4) -0.43709657 
Log P 2.236831  Molar Refractivity 48.4798 cm3
Polarizability 19.21153 Å3 Polar Surface Area 12.03 Å2
Rotatable Bonds Lipinski's Rule of Five true 

PROPERTIES

PROPERTIES

Physical Property Safety Information Product Information Bioassay(PubChem)
Solubility
DMSO expand Show data source
ethanol: soluble expand Show data source
H2O: soluble expand Show data source
Methanol expand Show data source
Water expand Show data source
Apperance
Off-White Solid expand Show data source
Melting Point
166-168°C expand Show data source
Flash Point
11 °C expand Show data source
51.8 °F expand Show data source
Storage Condition
Controlled Substance, -20°C Freezer expand Show data source
RTECS
SH5455000 expand Show data source
European Hazard Symbols
Flammable Flammable (F) expand Show data source
Toxic Toxic (T) expand Show data source
UN Number
1230 expand Show data source
2811 expand Show data source
MSDS Link
Download expand Show data source
German water hazard class
1 expand Show data source
3 expand Show data source
Hazard Class
3 expand Show data source
6.1 expand Show data source
Packing Group
2 expand Show data source
3 expand Show data source
Risk Statements
11-23/24/25-39/23/24/25 expand Show data source
25 expand Show data source
Safety Statements
16-36/37-45 expand Show data source
45 expand Show data source
GHS Pictograms
GHS02 expand Show data source
GHS06 expand Show data source
GHS08 expand Show data source
GHS Signal Word
Danger expand Show data source
GHS Hazard statements
H225-H301-H311-H331-H370 expand Show data source
H301 expand Show data source
GHS Precautionary statements
P210-P260-P280-P301 + P310-P311 expand Show data source
P301 + P310 expand Show data source
Personal Protective Equipment
Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US) expand Show data source
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges expand Show data source
RID/ADR
UN 1230 3/PG 2 expand Show data source
UN 2811 6.1/PG 3 expand Show data source
Drug Control
Home Office Schedule 2; stupéfiant; kontrollierte Droge in Deutschland expand Show data source
USDEA Schedule II; Home Office Schedule 2; stupéfiant; kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada expand Show data source
Storage Temperature
2-8°C expand Show data source
Concentration
1.0 mg/mL±5% in methanol expand Show data source
Grade
analytical standard, for drug analysis expand Show data source
Certificate of Analysis
Download expand Show data source

DETAILS

DETAILS

Sigma Aldrich Sigma Aldrich TRC TRC
Sigma Aldrich - M8750 external link
Biochem/physiol Actions
Sympathomimetic with more potent central effects than amphetamine. It is transported into terminals via the monoamine transporters and induces release of dopamine, norepinephrine, epinephrine, and serotonin. Dopamine release is important for the addictive properties of methamphetamine while norepinephrine and epinephrine release are important for the cardiovascular effects. Serotonin neurotoxin.
Toronto Research Chemicals - M258790 external link
A CNS stimulant. Anorexic. In attention deficit disorder with hyperactivity. Controlled substance (stimulant).

REFERENCES

REFERENCES

From Suppliers Google Scholar IconGoogle Scholar PubMed iconPubMed Google Books IconGoogle Books
  • • Lands, M., et al.: J. Pharmacol. Exp. Ther., 89, 382 (1947)
  • • Repke, D.B., et al.: J. Pharm. Sci., 67, 1167 (1947)
  • • Pope, H.G., et al.: J. Clin. Psychiatry, 47, 339 (1947)
  • • Cho, A.K., et al.: Science, 249, 631 (1947)
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PATENTS

PATENTS

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INTERNET

INTERNET

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