1-bromo-3-chloropropane

• ChemBase ID: 109499
• Molecular Formular: C3H6BrCl
• Molecular Mass: 157.43674
• Monoisotopic Mass: 155.93413987
• SMILES: ClCCCBr
• Canonical SMILES: ClCCCBr
• InChI: InChI=1S/C3H6BrCl/c4-2-1-3-5/h1-3H2
• InChIKey: MFESCIUQSIBMSM-UHFFFAOYSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: 1-bromo-3-chloropropane
• IUPAC Traditional name: 1-chloro-3-bromopropane
• Synonyms: 1-Chloro-3-bromopropane; 3-Bromo-1-chloropropane; 3-Bromopropyl Chloride; 3-Chloro-1-bromopropane; 3-Chloropropan-1-yl Bromide; 3-Chloropropyl Bromide; NSC 9183; Trimethylene Bromide Chloride; ω-Chlorobromopropane; 1-BROMO-3-CHLOROPROPANE; I-BCP; 1-Bromo-3-chloropropane; Trimethylene bromochloride; Trimethylene chlorobromide; 1,3-溴氯丙烷; 三亚甲基氯溴化合物; 1-溴-3-氯丙烷

Database IDs

• CAS Number: 109-70-6
• EC Number: 203-697-1
• MDL Number: MFCD00000998
• Beilstein Number: 605278
• PubChem SID: 162095222; 24891900; 24892149
• PubChem CID: 8006

CALCULATED PROPERTIES

• H Acceptors: 0
• H Donor: 0
• LogD (pH = 5.5): 1.7459596
• LogD (pH = 7.4): 1.7459596
• Log P: 1.7459596
• Molar Refractivity: 28.5045 cm^3
• Polarizability: 11.027107 Å^3
• Polar Surface Area: 0.0 Å^2
• Rotatable Bonds: 2
• Lipinski's Rule of Five: true

PROPERTIES

Physical Property

• Melting Point: -59°C; -59°C
• Boiling Point: 142-145°C; 144-145 °C(lit.)
• Flash Point: >140°C(284°F); 113 °F; 45 °C
• Density: 1.592 g/mL at 25 °C(lit.); 1.5969 g/ml; 1.598
• Refractive Index: 1.4855; n20/D 1.486; n20/D 1.486(lit.)

Safety Information

• RTECS: TX4113000
• European Hazard Symbols: X; Harmful (Xn)
• UN Number: 2688; UN2688
• German water hazard class: 3
• Hazard Class: 6.1
• Packing Group: 3; III
• Risk Statements: 10-20/22; 20/22-52/53; R:22
• Safety Statements: 16; 9-23-36-61; S:36/37/39
• TSCA Listed: 是
• GHS Pictograms: GHS02; GHS06
• GHS Signal Word: Danger
• GHS Hazard statements: H226-H302-H331; H331-H302-H402-H412
• GHS Precautionary statements: P261-P311; P261-P321-P304+P340-P311-P405-P501A
• Personal Protective Equipment: Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• RID/ADR: UN 2688 6.1/PG 3

Product Information

• Purity: ≥98.0% (GC); ≥99%; 99%
• Grade: purum
• Linear Formula: Cl(CH2)3Br

DETAILS

MP Biomedicals - 05211313

MP Biomedicals Rare Chemical collection

Sigma Aldrich - B9673

Application
BCP can be used in place of chloroform, and is less toxic. The use of BCP in the single-step TRI® Reagent method decreases the possibility of contaminating RNA with DNA. It does not adversely affect quality or quantity of the isolated RNA.
包装
200 mL in glass bottle

Sigma Aldrich - B62404

Packaging
1 kg in glass bottle
250 g in glass bottle

Toronto Research Chemicals - B682450

1-Bromo-3-chloropropane can be used safer and equally efficient alternative to chloroform as a phase-separation agent in the 1-step method of RNA isolation from biological samples such as animal and plant tissue.

REFERENCES

• Chomczynski, P. et al.: Anal. Biochem., 225, 163 (1995)
• Chey, S. et al.: Anal. Biochem., 411, 164 (1995)