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75-75-2 molecular structure
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methanesulfonic acid

ChemBase ID: 107832
Molecular Formular: CH4O3S
Molecular Mass: 96.10566
Monoisotopic Mass: 95.98811499
SMILES and InChIs

SMILES:
CS(=O)(=O)O
Canonical SMILES:
CS(=O)(=O)O
InChI:
InChI=1S/CH4O3S/c1-5(2,3)4/h1H3,(H,2,3,4)
InChIKey:
AFVFQIVMOAPDHO-UHFFFAOYSA-N

Cite this record

CBID:107832 http://www.chembase.cn/molecule-107832.html

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NAMES AND DATABASE IDS

NAMES AND DATABASE IDS

Names Database IDs
IUPAC name
methanesulfonic acid
IUPAC Traditional name
mesylate
methanesulfonic acid
Synonyms
Methanesulfonic acid solution
Methanesulfonic acid solution
Methanesulfonic acid concentrate
METHANESULFONIC ACID, 70% SOLUTION
Methylsulfonic acid
MSA
Methanesulfonic acid
Methanesulfonic acid
Mesic acid
甲烷磺酸 溶液
甲基磺酸
甲磺酸
CAS Number
75-75-2
EC Number
200-898-6
231-791-2
MDL Number
MFCD00007518
Beilstein Number
1446024
Merck Index
145954
PubChem SID
24890163
24870726
24896907
24850732
162095461
24870724
24879176
24873902
PubChem CID
6395
CHEBI ID
27376
Chemspider ID
6155
Unique Ingredient Identifier
12EH9M7279
Wikipedia Title
Methanesulfonic_acid

CALCULATED PROPERTIES

CALCULATED PROPERTIES

JChem
Acid pKa -1.6106497  H Acceptors
H Donor LogD (pH = 5.5) -3.3367643 
LogD (pH = 7.4) -3.3367722  Log P -0.9603736 
Molar Refractivity 16.5315 cm3 Polarizability 7.422034 Å3
Polar Surface Area 54.37 Å2 Rotatable Bonds
Lipinski's Rule of Five true 

PROPERTIES

PROPERTIES

Physical Property Safety Information Product Information Bioassay(PubChem)
Apperance
brown expand Show data source
Melting Point
17-19 °C(lit.) expand Show data source
17–19 °C expand Show data source
19-20°C expand Show data source
20°C expand Show data source
Boiling Point
166-168°C/10mm expand Show data source
167 °C/10 mmHg(lit.) expand Show data source
167 °C /10 mmHg, 122 °C/1 mmHg expand Show data source
Flash Point
>110°C(230°F) expand Show data source
156°C(312°F) expand Show data source
170 °C expand Show data source
189 °C expand Show data source
338 °F expand Show data source
372.2 °F expand Show data source
Density
1.039 g/mL at 20 °C expand Show data source
1.319 g/mL at 25 °C expand Show data source
1.320 expand Show data source
1.475-1.485 g/mL at 20 °C expand Show data source
1.48 g/cm3 expand Show data source
1.481 expand Show data source
1.481 g/mL at 25 °C(lit.) expand Show data source
Refractive Index
1.4150 expand Show data source
1.4300 expand Show data source
n20/D 1.415 expand Show data source
n20/D 1.416 expand Show data source
n20/D 1.429 expand Show data source
n20/D 1.429(lit.) expand Show data source
Vapor Pressure
<1 mmHg ( 20 °C) expand Show data source
1 mmHg ( 20 °C) expand Show data source
Vapor Density
3.3 (vs air) expand Show data source
Absorption Wavelength
λ: 210 nm Amax: ≤0.2 expand Show data source
λ: 220 nm Amax: ≤0.15 expand Show data source
λ: 230 nm Amax: ≤0.10 expand Show data source
λ: 240 nm Amax: 0.02 expand Show data source
λ: 240-320 nm Amax: <0.4 expand Show data source
λ: 250 nm Amax: 0.01 expand Show data source
λ: 260 nm Amax: ≤0.05 expand Show data source
λ: 260 nm Amax: 0.01 expand Show data source
λ: 500 nm Amax: ≤0.05 expand Show data source
pKa
-1.9 expand Show data source
Storage Warning
Light Sensitive & Hygroscopic expand Show data source
RTECS
PB1140000 expand Show data source
European Hazard Symbols
Corrosive Corrosive (C) expand Show data source
UN Number
2586 expand Show data source
2922 expand Show data source
3265 expand Show data source
UN2586 expand Show data source
MSDS Link
Download expand Show data source
Download expand Show data source
Download expand Show data source
Download expand Show data source
Download expand Show data source
Download expand Show data source
Download expand Show data source
Download expand Show data source
Download expand Show data source
Download expand Show data source
Download expand Show data source
Download expand Show data source
Download expand Show data source
Download expand Show data source
German water hazard class
1 expand Show data source
2 expand Show data source
nwg expand Show data source
Hazard Class
8 expand Show data source
Packing Group
2 expand Show data source
3 expand Show data source
III expand Show data source
Risk Statements
21/22-34 expand Show data source
21/22-35 expand Show data source
34 expand Show data source
R:34 expand Show data source
Safety Statements
20-23-26-36/37/39-45-60 expand Show data source
26-36/37/39-45 expand Show data source
26-36-45 expand Show data source
S:26-36-45 expand Show data source
TSCA Listed
expand Show data source
GHS Pictograms
GHS05 expand Show data source
GHS07 expand Show data source
GHS Signal Word
Danger expand Show data source
GHS Hazard statements
H290-H302 + H312-H314 expand Show data source
H290-H302-H314 expand Show data source
H290-H314 expand Show data source
H314 expand Show data source
GHS Precautionary statements
P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501A expand Show data source
P280-P305 + P351 + P338-P310 expand Show data source
Personal Protective Equipment
Eyeshields, Gloves expand Show data source
Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter expand Show data source
RID/ADR
UN 2586 8/PG 3 expand Show data source
UN 2922 8/PG 2 expand Show data source
UN 3265 8/PG 2 expand Show data source
Storage Temperature
2-8°C expand Show data source
Purity
≥98.0% (T) expand Show data source
≥99.0% (T) expand Show data source
≥99.5% expand Show data source
70% aq. soln. expand Show data source
98.0-102.0% (1 M NaOH, T) expand Show data source
98+% expand Show data source
Concentration
~1 M in H2O expand Show data source
~50% in H2O expand Show data source
~70% in H2O expand Show data source
0.1 M CH3SO3H in H2O (0.1N) expand Show data source
4 M (with 0.2% (w/v) tryptamine) expand Show data source
4.0 M±0.1 M in H2O (T) expand Show data source
70 wt. % in H2O expand Show data source
Grade
anhydrous expand Show data source
electronic grade expand Show data source
for HPCE expand Show data source
for ion chromatography expand Show data source
for protein sequence analysis expand Show data source
puriss. expand Show data source
purum expand Show data source
technical expand Show data source
Certificate of Analysis
Download expand Show data source
Suitability
corresponds for IR spectroscopy expand Show data source
corresponds to standard for RP gradient test expand Show data source
in accordance for filter test expand Show data source
Evaporation Residue
≤0.1% expand Show data source
Impurities
<0.5% water expand Show data source
≤1,000 ppm Sulfate (SO4) expand Show data source
≤10 ppm Iron expand Show data source
≤5 ppm ethyl methansesulfonate (GC) expand Show data source
≤5 ppm heavy metals expand Show data source
≤5 ppm methyl methanesulfonate (GC) expand Show data source
≤50 ppm Chloride (Cl) expand Show data source
impurities reacting with OPA reagent, none detected(fluorescence test) expand Show data source
Cation Traces
Al: ≤0.01 mg/kg expand Show data source
Ba: ≤0.01 mg/kg expand Show data source
Bi: ≤0.01 mg/kg expand Show data source
Ca: ≤0.05 mg/kg expand Show data source
Cd: ≤0.01 mg/kg expand Show data source
Co: ≤0.01 mg/kg expand Show data source
Cr: ≤0.01 mg/kg expand Show data source
Cu: ≤0.01 mg/kg expand Show data source
Fe: ≤0.05 mg/kg expand Show data source
K: ≤0.05 mg/kg expand Show data source
Li: ≤0.01 mg/kg expand Show data source
Mg: ≤0.01 mg/kg expand Show data source
Mn: ≤0.01 mg/kg expand Show data source
Mo: ≤0.01 mg/kg expand Show data source
Na: ≤0.10 mg/kg expand Show data source
Ni: ≤0.01 mg/kg expand Show data source
Pb: ≤0.01 mg/kg expand Show data source
Sr: ≤0.01 mg/kg expand Show data source
Zn: ≤0.01 mg/kg expand Show data source
Antion Traces
chloride (Cl-): ≤50 ppm expand Show data source
sulfate (SO42-): ≤100 ppm expand Show data source
Quality Level
GMP expand Show data source
Quality
ampule expand Show data source
λ
H2O reference expand Show data source
neat expand Show data source
Linear Formula
CH3SO3H expand Show data source

DETAILS

DETAILS

Wikipedia Wikipedia Sigma Aldrich Sigma Aldrich
Sigma Aldrich - 516724 external link
Legal Information
Product of Arkema
Sigma Aldrich - 516848 external link
Legal Information
Product of Arkema
Sigma Aldrich - 64280 external link
Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Sigma Aldrich - 55517 external link
General description
This certified eluent concentrate for ion chromatography is traceable by potentiometric titration to NIST Standard Reference Material. It is certified in accordance with ISO Guide 31. All details about exact content, uncertainty, traceability and expiry date are described in the certificate.Download at: http://www.sigma-aldrich.com.
Preparation Note
Prepared with methanesulfonic acid and high purity water (18.2 MΩ, 0.2 μm filtered)
Sigma Aldrich - 64291 external link
Packaging
ampoules 10 x 1 ml
Sigma Aldrich - 471348 external link
Packaging
1 L in glass bottle
100, 500 mL in glass bottle
18 L in poly drum
Legal Information
Product of Arkema Inc.
Sigma Aldrich - 471356 external link
Packaging
100, 500 mL in poly bottle
5 L in poly drum
2 L in glass bottle
2.5 L in poly bottle
5, 25 mL in glass bottle
Sigma Aldrich - M4141 external link
Application
For complete protein and peptide hydrolysis with tryptophan recovery. After hydrolysis the samples are diluted prior to amino acid analysis.
Packaging
Ampules sealed under argon.

REFERENCES

REFERENCES

From Suppliers Google Scholar IconGoogle Scholar PubMed iconPubMed Google Books IconGoogle Books
  • • Strong acid which has been used for the deprotection of peptides; see Appendix 6.
  • • Cleaves methyl ethers of phenols in the presence of the soft nucleophile methionine as a methyl acceptor. Polymethoxyaldehydes or ketones undergo selective cleavage of the methoxy group meta to the carbonyl: J. Chem. Soc., Perkin 1, 2288 (1977). Similarly, in combination with dimethyl sulfide, selective O-demethylation of mixed phosphate esters occurs: Synthesis, 451 (1983).
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PATENTS

PATENTS

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INTERNET

INTERNET

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