3,12-bis(carboxymethyl)-6,9-dioxa-3,12-diazatetradecanedioic acid

• ChemBase ID: 105857
• Molecular Formular: C14H24N2O10
• Molecular Mass: 380.34776
• Monoisotopic Mass: 380.14309498
• SMILES: OC(=O)CN(CCOCCOCCN(CC(=O)O)CC(=O)O)CC(=O)O
• Canonical SMILES: OC(=O)CN(CC(=O)O)CCOCCOCCN(CC(=O)O)CC(=O)O
• InChI: InChI=1S/C14H24N2O10/c17-11(18)7-15(8-12(19)20)1-3-25-5-6-26-4-2-16(9-13(21)22)10-14(23)24/h1-10H2,(H,17,18)(H,19,20)(H,21,22)(H,23,24)
• InChIKey: DEFVIWRASFVYLL-UHFFFAOYSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: 3,12-bis(carboxymethyl)-6,9-dioxa-3,12-diazatetradecanedioic acid
• IUPAC Traditional name: EGTA
• Synonyms: Ethylenebis(oxyethylenenitrilo)tetraacetic acid; Ethylene glycol-O,O'-bis(2-aminoethyl)-N,N,N',N'-tetraacetic acid; EGTA (chemical); Ethylenebis(oxyethylenenitrilo)tetraacetic acid; ETHYLENEGLYCOL-bis-(β-AMINOETHYLETHER)-N,N'-TETRAACETIC ACID; ETHYLENE GLYCOL-bis-(β-AMINOETHYLETHER)-N,N,N',N'-TETRAACETIC ACID; EGTA; ETHYLENE GLYCOL-bis-(β-AMINO-ETHYLETHER)-N,N,N',N'-TETRAACETIC ACID; Chel™-DE; Ethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid; Egtazic acid; Ethylene-bis(oxyethylenenitrilo)tetraacetic acid; Glycol ether diamine tetraacetic acid; 乙二醇-O,O'-双(2-氨乙基)-N,N,N',N'-四乙酸; 乙二醇二乙醚二胺四乙酸; 乙二醇双氨乙基醚四乙酸; 依他酸; 乙二醇双(2-氨基乙基醚)四乙酸

Database IDs

• CAS Number: 67-42-5
• EC Number: 200-651-2
• MDL Number: MFCD00004291
• Beilstein Number: 1717370
• Merck Index: 143529
• PubChem SID: 162092617; 24845592; 24894530; 24845591; 24894367; 24278421
• PubChem CID: 6207
• CHEBI ID: 30740
• CHEMBL: 240390
• Chemspider ID: 5972
• KEGG ID: D00569
• Unique Ingredient Identifier: 526U7A2651
• Wikipedia Title: EGTA_(chemical)

CALCULATED PROPERTIES

• Acid pKa: 2.1556778
• H Acceptors: 12
• H Donor: 4
• LogD (pH = 5.5): -11.342245
• LogD (pH = 7.4): -14.649551
• Log P: -7.2473655
• Molar Refractivity: 84.4326 cm^3
• Polarizability: 33.452957 Å^3
• Polar Surface Area: 174.14 Å^2
• Rotatable Bonds: 17
• Lipinski's Rule of Five: false

PROPERTIES

Physical Property

• Solubility: 0.1 M NaOH: soluble0.1 M at 20 °C, clear, colorless; 1 M NaOH: soluble0.1 M at 20 °C, clear, colorless; H2O: soluble (increases as pH is increased)
• Melting Point: ~250 °C (dec.); 241 °C (dec.)(lit.); 241°C; 241°C (Decomposes); 245-255 °C; ca 242°C dec.

Safety Information

• Storage Condition: Room Temperature (15-30°C)
• RTECS: AH3760000
• German water hazard class: 2
• TSCA Listed: 是
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

Product Information

• Purity: ≥97%; ~98%; ≥97%; ≥97.0%; ≥98.0% (T); ≥98.5%; ≥98.5% (calc. to the dried substance); ≥99.0% (T); 97%
• Grade: for complexometry; for molecular biology
• Ignition Residue: <0.1%; ≤0.05% (as SO4); ≤0.1% (as SO4)
• Impurities: <0.0005% Phosphorus (P); <0.1% Insoluble matter; ≤0.001% heavy metals (as Pb); DNases, none detected; insoluble matter, passes filter test; phosphatases, none detected; proteases, none detected; RNases, none detected
• Cation Traces: Al: <0.0005%; Al: ≤5 mg/kg; As: ≤0.1 mg/kg; Ba: ≤5 mg/kg; Bi: ≤5 mg/kg; Ca: <0.0005%; Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: <0.0005%; Cu: ≤5 mg/kg; Fe: <0.0005%; Fe: ≤10 mg/kg; Fe: ≤5 mg/kg; K: <0.005%; K: ≤50 mg/kg; Li: ≤5 mg/kg; Mg: <0.0005%; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Mo: ≤5 mg/kg; Na: <0.05%; Na: ≤200 mg/kg; NH4+: <0.05%; Ni: ≤5 mg/kg; Pb: <0.001%; Pb: ≤5 mg/kg; Sr: ≤5 mg/kg; Zn: <0.0005%; Zn: ≤5 mg/kg
• Antion Traces: sulfate (SO42-): <0.05%; sulfate (SO42-): ≤400 mg/kg; sulfate (SO42-): ≤50 mg/kg
• Foreign Activity: DNAse (exonuclease), NICKase (endonuclease), RNAse, and protease, none detected
• Loss on Drying: ≤1% loss on drying, 150 °C; ≤1.0% loss on drying; ≤1.0% loss on drying, 110 °C
• Quality Level: ELITE; PREMIUM
• Product Line: BioUltra
• abs.: absorption0.1M/263 nm, 1 M NaOH cut-off
• Linear Formula: [-CH2OCH2CH2N(CH2CO2H)2]2

DETAILS

MP Biomedicals - 02195174

(EGTA) Crystalline Purity: ~98% Chelating agent for determination of calcium in the presence of magnesium.

MP Biomedicals - 02194823

Molecular Biology Reagent
Purity: >97%

Sigma Aldrich - E3889

Application
可用于在存在镁的情况下测定钙的螯合剂。
法律信息
Chel 商标 Ciba-Geigy AG

Sigma Aldrich - 234532

Application
A chelating agent useful for the determination of calcium in the presence of magnesium.

Sigma Aldrich - 34596

Application
A chelating agent useful for the determination of calcium in the presence of magnesium.
General description
Visit our Titration Center to learn more.

Sigma Aldrich - 03779

Application
A chelating agent useful for the determination of calcium in the presence of magnesium.
General description
Visit our Titration Center to learn more.
Other Notes
Reagent for the determination of calcium1

Sigma Aldrich - E0396

Application
A chelating agent useful for the determination of calcium in the presence of magnesium.

Sigma Aldrich - 03777

Application
A chelating agent useful for the determination of calcium in the presence of magnesium.
Ethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid can be used to study molecular biology, biochemicals, reagents and chelators. Ethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid has been used in a study that illustrated the response of the β-cyclodextrin-hemin complex in the induction of cucumber adventitious rooting through heme oxygenase-1-dependent mechanism and calcium signaling.
Other Notes
Buffer component in dideoxy sequencing of RNA using reverse transcriptase1.

Sigma Aldrich - 03780

Application
A chelating agent useful for the determination of calcium in the presence of magnesium.

Sigma Aldrich - E4378

Application
可用于在存在镁的情况下测定钙的螯合剂。
包装
1 kg in poly bottle
10, 25, 100, 250, 500 g in poly bottle
Physical properties
在水中的溶解性随 pH 值增加而增加
法律信息
Chel 商标 Ciba-Geigy AG

Sigma Aldrich - 03778

Application
A chelating agent useful for the determination of calcium in the presence of magnesium.

REFERENCES

• Schmidt, R.W. and Reilly, C.N., Anal. Chem. , 29 : 264 (1957).
• Reagent for complexometry.