7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol hydrobromide

• ChemBase ID: 105154
• Molecular Formular: C16H26BrNO
• Molecular Mass: 328.28774
• Monoisotopic Mass: 327.11977646
• SMILES: Br.CCCN(CCC)C1CCc2cccc(O)c2C1
• Canonical SMILES: CCCN(C1CCc2c(C1)c(O)ccc2)CCC.Br
• InChI: InChI=1S/C16H25NO.BrH/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14;/h5-7,14,18H,3-4,8-12H2,1-2H3;1H
• InChIKey: BATPBOZTBNNDLN-UHFFFAOYSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: 7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol hydrobromide
• IUPAC Traditional name: 8-OH-dpat hydrobromide
• Synonyms: (±)-8-OH-DPAT; (±)-8-Hydroxy-2-(dipropylamino)tetralin; (±)-8-Hydroxy-2-(dipropylamino)tetralin hydrobromide; (±)-8-Hydroxy-DPAT; (±)-8-HYDROXY-2-DIPROPYLAMINOTETRALIN HYDROBROMIDE; 7-(Dipropylamino)-5,6,7,8-tetrahydro-1-naphthalenol Hydrobromide; (+/-)-8-Hydroxy(N,N-dipropyl-2-amino)tetralin Hydrobromide; 8-OH DPAT; rac-8-Hydroxy-2-dipropylaminotetralin Hydrobromide; (±)-2-二丙基氨基-8-羟基-1,2,3,4-四氢萘; (±)-8-羟基-2-(二丙基氨基)四氢萘 氢溴酸盐

Database IDs

• CAS Number: 76135-31-4; 87394-87-4
• MDL Number: MFCD00055158
• PubChem SID: 162092523; 24895825
• PubChem CID: 6917794

CALCULATED PROPERTIES

• Acid pKa: 9.8180685
• H Acceptors: 2
• H Donor: 1
• LogD (pH = 5.5): 0.726973
• LogD (pH = 7.4): 1.4670886
• Log P: 3.539658
• Molar Refractivity: 77.4626 cm^3
• Polarizability: 30.019728 Å^3
• Polar Surface Area: 23.47 Å^2
• Rotatable Bonds: 5
• Lipinski's Rule of Five: true

PROPERTIES

Safety Information

• Storage Condition: Room Temperature (15-30°C)
• European Hazard Symbols: Irritant (Xi)
• German water hazard class: 3
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• GHS Pictograms: GHS07
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• GHS Precautionary statements: P261-P305 + P351 + P338
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves

Product Information

• Purity: ≥98%; 99%

DETAILS

MP Biomedicals - 02158933

Hydrobromide
Purity: 99%
Specific 5-HT_1a agonist.

Sigma Aldrich - H8520

Biochem/physiol Actions
选择性 5-HT1 激动剂1，对亚型 5-HT1A 受体具有高亲和性。2,3
包装
100 mg in glass bottle
25 mg in poly bottle

Toronto Research Chemicals - H941450

Dopamine receptor Agonist.

REFERENCES

• Middlemiss, D.N., et al., Eur. J. Pharmacol. , 90 : 151 (1983).
• Zahorodna, A., et al.: J. Physiol. Pharmacol., 55, 371 (2004)
• Thompson, M., et al.: Prog. Neuro-Psychopharmacol. Biol. Psych., 32, 1013 (2004)
• Li, J., et al.: J. Pharmacol. Exper. Ther., 324, 827 (2004)