4-(trimethylsilyl)morpholine

• ChemBase ID: 104758
• Molecular Formular: C7H17NOSi
• Molecular Mass: 159.30148
• Monoisotopic Mass: 159.1079407
• SMILES: C[Si](C)(C)N1CCOCC1
• Canonical SMILES: C[Si](N1CCOCC1)(C)C
• InChI: InChI=1S/C7H17NOSi/c1-10(2,3)8-4-6-9-7-5-8/h4-7H2,1-3H3
• InChIKey: JJOWIQMPCCUIGA-UHFFFAOYSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: 4-(trimethylsilyl)morpholine
• IUPAC Traditional name: 4-(trimethylsilyl)morpholine
• Synonyms: 4-(Trimethylsilyl)morpholine; 4-(trimethylsilyl)morpholine; N-(TRIMETHYLSILYL) MORPHOLINE; N-(Trimethylsilyl)morpholine; 4-(三甲基硅基)吗啉

Database IDs

• CAS Number: 13368-42-8
• MDL Number: MFCD00010098
• Beilstein Number: 1071480
• PubChem SID: 24855821; 162092305
• PubChem CID: 559763

CALCULATED PROPERTIES

• H Acceptors: 2
• H Donor: 0
• LogD (pH = 5.5): -2.3862677
• LogD (pH = 7.4): -1.321257
• Log P: 0.8239
• Molar Refractivity: 40.3082 cm^3
• Polarizability: 18.044262 Å^3
• Polar Surface Area: 12.47 Å^2
• Rotatable Bonds: 1
• Lipinski's Rule of Five: true

PROPERTIES

Physical Property

• Melting Point: 188 - 190°C
• Boiling Point: 160 °C(lit.); 160°C; 160°C
• Flash Point: 27°C; 29 °C; 29°C(84°F); 84.2 °F
• Density: 0.897; 0.897 g/ml; 0.897 g/mL at 25 °C(lit.)
• Refractive Index: 1.4410; n20/D 1.441(lit.)
• Hydrophobicity(logP): 1.323

Safety Information

• Storage Condition: 2-8°C, Store Under Nitrogen
• European Hazard Symbols: Corrosive (C); Flammable (F)
• UN Number: 1993; 2924; UN2924
• German water hazard class: 3
• Hazard Class: 3; 8
• Packing Group: 3; II
• Australian Hazchem: 3WE
• Risk Statements: 10-34; R:10-34
• Safety Statements: 20-23-26-36/37/39-45-60; 26-36/37/39-45; S:16-23-26-36/37/39
• EU Classification: FC
• EU Hazard Identification Number: 8A
• Emergency Response Guidebook(ERG) Number: 132
• TSCA Listed: 否
• GHS Pictograms: GHS02; GHS05
• GHS Signal Word: Danger
• GHS Hazard statements: H226-H314; H314-H318-H226
• GHS Precautionary statements: P210-P241-P303+P361+P353-P305+P351+P338-P405-P501A; P280-P305 + P351 + P338-P310
• Personal Protective Equipment: Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• RID/ADR: UN 1993 3/PG 3

Product Information

• Purity: 95%; 97%
• Empirical Formula (Hill Notation): C7H17NOSi

DETAILS

MP Biomedicals - 02157096

Reagent for oligonucleotide synthesis.

Sigma Aldrich - 261599

Packaging
5, 25 g in glass bottle
Application
Reagent for deoxynucleoside synthesis.

REFERENCES

• McBride, L. and Caruthers, M., Tet. Lett. , 24 : 245, (1983).