sodium 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethane-1-sulfonate

• ChemBase ID: 102927
• Molecular Formular: C8H17N2NaO4S
• Molecular Mass: 260.28635
• Monoisotopic Mass: 260.08067232
• SMILES: [Na+].OCCN1CCN(CC1)CCS(=O)(=O)[O-]
• Canonical SMILES: OCCN1CCN(CC1)CCS(=O)(=O)[O-].[Na+]
• InChI: InChI=1S/C8H18N2O4S.Na/c11-7-5-9-1-3-10(4-2-9)6-8-15(12,13)14;/h11H,1-8H2,(H,12,13,14);/q;+1/p-1
• InChIKey: RDZTWEVXRGYCFV-UHFFFAOYSA-M

NAMES AND DATABASE IDS

Names

• IUPAC name: sodium 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethane-1-sulfonate
• IUPAC Traditional name: sodium 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonate; potassium 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonate
• Synonyms: HEPES hemisodium salt; HEPES sodium salt solution; 4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid sodium salt; HEPES sodium salt; 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid sodium salt; N-(2-Hydroxyethyl)piperazine-N'-(2-ethanesulfonic acid) sodium salt; HEPES SODIUM SALT; 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid hemisodium salt; N-(2-Hydroxyethyl)piperazine-N'-(2-ethanesulfonic acid) hemisodium salt; HEPES; 4-(2-羟乙基)哌嗪-1-乙磺酸 半钠盐; N-(2-羟乙基)哌嗪-N′-(2-乙磺酸) 半钠盐; HEPES 半钠盐; HEPES 钠盐 溶液; HEPES钠盐; 4-(2-羟乙基)哌嗪-1-乙磺酸 钠盐; N-(2-羟乙基)哌嗪-N′-(2-乙磺酸) 钠盐; HEPES 钠 钠盐

Database IDs

• CAS Number: 75277-39-3; 103404-87-1
• EC Number: 278-169-7
• MDL Number: MFCD00036463
• PubChem SID: 24895802; 24895595; 24895527; 24895780; 24895874; 24895590; 162090775
• PubChem CID: 2724248

CALCULATED PROPERTIES

• H Donor: 1
• LogD (pH = 5.5): -3.1127214
• LogD (pH = 7.4): -3.2495832
• Log P: -3.111727
• Molar Refractivity: 55.8951 cm^3
• Polarizability: 23.015087 Å^3
• Polar Surface Area: 83.91 Å^2
• Rotatable Bonds: 5
• Lipinski's Rule of Five: true
• Acid pKa: -1.3356507
• H Acceptors: 6

PROPERTIES

Physical Property

• Solubility: H2O: soluble1 M, clear, colorless
• Apperance: dry powder
• Absorption Wavelength: A1M/260, H2O ≤0.2; A1M/260, H2O ≤0.4; A1M/280, H2O ≤0.2
• pKa: 7.5
• pH: 10.0-12.0 (1 M in H2O)

Safety Information

• Storage Condition: Room Temperature (15-30°C); Room Temperature (15-30°C), Desiccate
• European Hazard Symbols: Irritant (Xi)
• German water hazard class: 3
• Risk Statements: R:36/37/38
• Safety Statements: S:20-25-26-37/39
• TSCA Listed: 是
• Personal Protective Equipment: Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US); Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

Product Information

• Purity: ~99%; ≥99% (titration); ≥99.5% (titration); 99%
• Suitability: suitable for cell culture
• Impurities: <5 ppm Heavy metals (as Pb); ≤0.005% Phosphorus (P); ≤0.1% Insoluble matter; Bioburden, tested; DNase, RNase. Protease, Nickase, free; endotoxin and total aerobic microbial count, tested; endotoxin, tested
• Cation Traces: Al: ≤0.0005%; Ca: ≤0.0005%; Cu: ≤0.0005%; Fe: <5 ppm; Fe: ≤0.0005%; Fe: ≤5 ppm; heavy metals (as Pb): ≤5 ppm; K: ≤0.005%; Mg: ≤0.0005%; NH4+: ≤0.05%; Pb: ≤0.001%; Zn: ≤0.0005%
• Antion Traces: chloride (Cl-): ≤0.05%; sulfate (SO42-): ≤0.05%
• Foreign Activity: DNase, RNase, NICKase, protease, none detected
• Sterility: sterile; 0.2 μm filtered
• pH Range: 6.8 - 8.2
• Quality Level: ELITE; GMP
• Product Line: BioReagent
• Empirical Formula (Hill Notation): C8H17N2NaO4S

DETAILS

MP Biomedicals - 02152451

Hemisodium Salt
0.5 mole sodium per mole Hepes.

MP Biomedicals - 02105593

Crystalline
Purity: ~99%
pKa=7.55 at 25°C

Sigma Aldrich - H7006

Other Notes
使用 HEPES 钠盐规格表可以非常方便地比较 HEPES 钠盐产品的规格。
包装
1 kg in poly bottle
2.5, 25 kg in poly drum
25, 100, 500 g in poly bottle
Physical form
冻干、喷雾干燥或结晶的材料。
Protocols & Applications
Ensure correct concentrations of buffer solutions with the Buffer Calculator

Sigma Aldrich - H8651

Other Notes
使用 HEPES 钠盐规格表可以非常方便地比较 HEPES 钠盐产品的规格。

Sigma Aldrich - H3784

Physical form
冻干、喷雾干燥或结晶的材料。

Sigma Aldrich - H9897

包装
锡箔袋包装
Reconstitution
每袋中的物质溶于 1 升去离子水可生成 0.1M 的 HEPES 钠盐缓冲液，25°C 下 pH 值为 7.5。