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5704-04-1 molecular structure
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2-{[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino}acetic acid

ChemBase ID: 102806
Molecular Formular: C6H13NO5
Molecular Mass: 179.17112
Monoisotopic Mass: 179.07937252
SMILES and InChIs

SMILES:
OCC(CO)(CO)NCC(=O)O
Canonical SMILES:
OCC(NCC(=O)O)(CO)CO
InChI:
InChI=1S/C6H13NO5/c8-2-6(3-9,4-10)7-1-5(11)12/h7-10H,1-4H2,(H,11,12)
InChIKey:
SEQKRHFRPICQDD-UHFFFAOYSA-N

Cite this record

CBID:102806 http://www.chembase.cn/molecule-102806.html

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NAMES AND DATABASE IDS

NAMES AND DATABASE IDS

Names Database IDs
IUPAC name
2-{[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino}acetic acid
IUPAC Traditional name
tricine
Synonyms
TRICINE, ELECTROPHORESIS GRADE
N-Tris-[hydroxymethyl]methylglycine
TRICINE
Tricine
N-(Tri(hydroxymethyl)methyl)glycine
Tricine
N-[Tris(hydroxymethyl)methyl]glycine
N-(Trishydroxymethylmethyl)glycine
N-三(羟甲基)甲基甘氨酸
三(羟甲基)甲基甘氨酸
N-(三羟甲基甲基)甘氨酸
CAS Number
5704-04-1
EC Number
227-193-6
MDL Number
MFCD00004277
Beilstein Number
1937804
Merck Index
149651
PubChem SID
162088290
24889851
24899930
24900603
24899884
24900318
PubChem CID
79784
CHEBI ID
39063
Chemspider ID
72078
Gmelin ID
3688
MeSH Name
tricine
Wikipedia Title
Tricine

CALCULATED PROPERTIES

CALCULATED PROPERTIES

JChem
Acid pKa 2.860766  H Acceptors
H Donor LogD (pH = 5.5) -5.245832 
LogD (pH = 7.4) -5.4276204  Log P -5.245555 
Molar Refractivity 39.2147 cm3 Polarizability 15.894165 Å3
Polar Surface Area 110.02 Å2 Rotatable Bonds
Lipinski's Rule of Five true 

PROPERTIES

PROPERTIES

Physical Property Safety Information Product Information Bioassay(PubChem)
Solubility
89.6 g L-1 (at 20 °C) in water expand Show data source
H2O: soluble0.5 M at 20 °C, clear expand Show data source
H2O: soluble0.5 M at 20 °C, clear, colorless expand Show data source
H2O: soluble1 M, clear, colorless expand Show data source
Apperance
White crystals expand Show data source
Melting Point
179-189°C (dec.) expand Show data source
186-188 °C (dec.) expand Show data source
187 °C expand Show data source
ca 183°C dec. expand Show data source
Absorption Wavelength
260 nm expand Show data source
A1M/260, H2O ≤0.1 expand Show data source
A1M/280, H2O ≤0.05 expand Show data source
A20%/290 ≤0.02 expand Show data source
λ: 260 nm Amax: 0.03 expand Show data source
λ: 280 nm Amax: 0.02 expand Show data source
pKa
8.1 expand Show data source
8.1 (25°C) expand Show data source
8.15 (20°C) expand Show data source
Absorbance
0.03 expand Show data source
pH
4.0-6.0 (1 M in H2O) expand Show data source
4.5-6.0 (25 °C, 0.5 M in H2O) expand Show data source
Storage Condition
Room Temperature (15-30°C) expand Show data source
MSDS Link
Download expand Show data source
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German water hazard class
3 expand Show data source
TSCA Listed
expand Show data source
Personal Protective Equipment
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter expand Show data source
Purity
>99% expand Show data source
≥99% (titration) expand Show data source
≥99.0% (NT) expand Show data source
≥99.5% (NT) expand Show data source
98% expand Show data source
98+% expand Show data source
Concentration
1 M in solution expand Show data source
Grade
Biotechnology Performance Certified expand Show data source
ELECTROPHORESIS expand Show data source
Certificate of Analysis
Download expand Show data source
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Suitability
cell culture tested expand Show data source
Ignition Residue
≤0.05% (as SO4) expand Show data source
≤0.1% expand Show data source
Impurities
<5 ppm heavy metals as (Pb) expand Show data source
≤0.005% Phosphorus (P) expand Show data source
≤0.1% Insoluble matter expand Show data source
bioburden, tested expand Show data source
DNase, RNase, Protease, none detected expand Show data source
endotoxin and bioburden, tested expand Show data source
endotoxin, tested expand Show data source
Insoluble matter, passes filter test expand Show data source
Cation Traces
Al: ≤0.0005% expand Show data source
Al: ≤5 mg/kg expand Show data source
As: ≤0.1 mg/kg expand Show data source
Ba: ≤5 mg/kg expand Show data source
Bi: ≤5 mg/kg expand Show data source
Ca: ≤0.0005% expand Show data source
Ca: ≤10 mg/kg expand Show data source
Cd: ≤5 mg/kg expand Show data source
Co: ≤5 mg/kg expand Show data source
Cr: ≤5 mg/kg expand Show data source
Cu: ≤0.0005% expand Show data source
Cu: ≤5 mg/kg expand Show data source
Fe: <5 ppm expand Show data source
Fe: ≤0.0005% expand Show data source
Fe: ≤5 mg/kg expand Show data source
heavy metals (as Pb): ≤5 ppm expand Show data source
K: ≤0.005% expand Show data source
K: ≤50 mg/kg expand Show data source
Li: ≤5 mg/kg expand Show data source
Mg: ≤0.0005% expand Show data source
Mg: ≤5 mg/kg expand Show data source
Mn: ≤5 mg/kg expand Show data source
Mo: ≤5 mg/kg expand Show data source
Na: ≤0.005% expand Show data source
Na: ≤50 mg/kg expand Show data source
NH4+: ≤0.05% expand Show data source
Ni: ≤5 mg/kg expand Show data source
Pb: ≤0.001% expand Show data source
Pb: ≤5 mg/kg expand Show data source
Sr: ≤5 mg/kg expand Show data source
Zn: ≤0.0005% expand Show data source
Zn: ≤5 mg/kg expand Show data source
Antion Traces
chloride (Cl-): ≤0.1% expand Show data source
chloride (Cl-): ≤1000 mg/kg expand Show data source
chloride (Cl-): ≤500 mg/kg expand Show data source
sulfate (SO42-): ≤0.05% expand Show data source
sulfate (SO42-): ≤50 mg/kg expand Show data source
Sterility
0.2 μm filtered expand Show data source
Loss on Drying
≤0.5% loss on drying, 110 °C expand Show data source
pH Range
7.4 - 8.8 expand Show data source
Quality Level
ELITE expand Show data source
GMP expand Show data source
λ
0.5 M in H2O expand Show data source
Useful pH Range
7.4 - 8.8 expand Show data source
7.6 - 8.8 expand Show data source
Product Line
BioUltra expand Show data source
Linear Formula
(HOCH2)3CNHCH2CO2H expand Show data source

DETAILS

DETAILS

MP Biomedicals MP Biomedicals Wikipedia Wikipedia Sigma Aldrich Sigma Aldrich
MP Biomedicals - 04807410 external link
Electrophoresis Grade
Purity: >99%
Heavy metals (as Pb): <10 ppm
pKa at 25°C = 8.1
Biological buffer
MP Biomedicals - 02194556 external link
(N-Tris-[hydroxymethyl]methylglycine) Cell Culture Reagent Biological buffer pKa at 25°C = 8.1 Buffering pH range 7.4-8.8
MP Biomedicals - 04807420 external link
Electrophoresis Grade Purity: >99% Heavy metals (as Pb): <10 ppm pKa at 25°C = 8.1 Biological buffer
MP Biomedicals - 02103112 external link
Biological buffer
pKa at 25°C = 8.1
Buffering pH range 7.4-8.8
MP Biomedicals - 04807416 external link
Electrophoresis Grade Purity: >99% Heavy metals (as Pb): <10 ppm pKa at 25°C = 8.1 Biological buffer
MP Biomedicals - 04807413 external link
Electrophoresis Grade Purity: >99% Heavy metals (as Pb): <10 ppm pKa at 25°C = 8.1 Biological buffer
Sigma Aldrich - 93356 external link
Application
Buffer component for separation of low molecular weight peptides.
Other Notes
Buffer for biological research1; In the optimization of the firefly luciferase assay for ATP2; Component of a non-barbiturate buffer system for electrophoresis of serum proteins on cellulose acetate membranes3.
Sigma Aldrich - T0377 external link
Application
用于分离低分子量的肽的缓冲剂组分。
包装
1 kg in poly bottle
25, 100, 250 g in poly bottle
5, 25 kg in poly drum
Sigma Aldrich - T1074 external link
Application
Buffer component for separation of low molecular weight peptides.
Sigma Aldrich - T9784 external link
Application
用于分离低分子量的肽的缓冲剂组分。
Sigma Aldrich - T5816 external link
Application
用于分离低分子量的肽的缓冲剂组分。
Quality
经过内毒素和生物负载测试
Sigma Aldrich - 93355 external link
Application
Buffer component for separation of low molecular weight peptides.
Other Notes
Biological buffer1

REFERENCES

REFERENCES

From Suppliers Google Scholar IconGoogle Scholar PubMed iconPubMed Google Books IconGoogle Books
  • • Biological buffer, pKa = 8.15 at 20o: Biochemistry, 5, 467 (1966).
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PATENTS

PATENTS

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INTERNET

INTERNET

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