3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57,60,63,66,69-tricosaoxahenoctacontan-1-ol

• ChemBase ID: 102315
• Molecular Formular: C58H118O24
• Molecular Mass: 1199.54312
• Monoisotopic Mass: 1198.80130466
• SMILES: CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO
• Canonical SMILES: CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO
• InChI: InChI=1S/C58H118O24/c1-2-3-4-5-6-7-8-9-10-11-13-60-15-17-62-19-21-64-23-25-66-27-29-68-31-33-70-35-37-72-39-41-74-43-45-76-47-49-78-51-53-80-55-57-82-58-56-81-54-52-79-50-48-77-46-44-75-42-40-73-38-36-71-34-32-69-30-28-67-26-24-65-22-20-63-18-16-61-14-12-59/h59H,2-58H2,1H3
• InChIKey: IEQAICDLOKRSRL-UHFFFAOYSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: 3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57,60,63,66,69-tricosaoxahenoctacontan-1-ol
• IUPAC Traditional name: 3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57,60,63,66,69-tricosaoxahenoctacontan-1-ol
• Synonyms: Polyethylene glycol dodecyl ether; Polyoxyethylene (23) lauryl ether; Brij® 35; Hydroxypolyethoxydodecane; Lauromacrogol; Macrogol lauryl ether; Polyethylene glycol 400 dodecyl ether; Thesit®; Polyethylene glycol dodecyl ether solution; Thesit® solution; Brij® L4; BRIJ 35; Polyoxyethylene 23 Lauryl Ether; Capillary coating solution; Brij 35; C12E23; Brij® L23; Brij® 35 solution; Brij® L23 solution; Polyoxyethylene 9-lauryl ether; Nonaethylene glycol monododecyl ether; Dodecyl nonaethylene glycol ether; Dodecylnonaglycol; Polidocanol; DODECYLPOLY(ETHYLENE GLYCOL ETHER); C12E10; Polyoxyethylene (10) lauryl ether; Decaethylene glycol mono-dodecyl ether; Brij? 35; Tricosaethylene glycol mono-n-dodecyl ether; 四聚乙二醇单月桂醚; 聚氧乙烯(23)月桂醚; 聚乙二醇 (400) 单月桂酸酯; 四聚乙二醇单月桂醚 溶液; Thesit® 溶液; Brij® 30; Brij® L23; 毛细管柱固定液; Brij® 35 溶液; Brij® L23 溶液; Brij? L23 聚氧乙烯月桂醚

Database IDs

• CAS Number: 3055-99-0; 9002-92-0
• EC Number: 500-002-6; 231-791-2; 221-284-4
• MDL Number: MFCD00080891
• Beilstein Number: 1900171
• PubChem SID: 24849848; 24889081; 24889082; 24849855; 24898176; 24849844; 24891758; 24849854; 162088508; 24899063
• PubChem CID: 2724258

CALCULATED PROPERTIES

• Acid pKa: 15.121156
• H Acceptors: 24
• H Donor: 1
• LogD (pH = 5.5): 3.2814345
• LogD (pH = 7.4): 3.2814345
• Log P: 3.2814345
• Molar Refractivity: 312.9434 cm^3
• Polarizability: 124.35176 Å^3
• Polar Surface Area: 232.52 Å^2
• Rotatable Bonds: 79
• Lipinski's Rule of Five: false

PROPERTIES

Physical Property

• Solubility: H2O: soluble0.1 g/mL, clear, very faintly yellow; H2O: soluble40 mg/mL at 20 °C, clear, colorless
• Apperance: semisolid (with melting point ~24 °C.)
• Melting Point: 39-43 °C; 41- 45°C; 41-45 °C(lit.); 41-45°C; ca 35-40°C
• Boiling Point: 100 °C(lit.); 100°C
• Flash Point: > 148°C; 113 °C; 235.4 °F
• Density: ~0.95 g/mL at 20 °C; 1.00 g/mL at 20 °C; 1.01 g/mL at 20 °C; 1.05 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.333; n20/D 1.346; n20/D 1.347; n20/D 1.453
• Vapor Pressure: <1 mmHg ( 20 °C)
• Critical Micelle Concentration: 0.09; 0.1; 0.1 mM(20-25°C); 91 μM
• Conductivity: ≤15 μS/cm at 20 °C
• Aggregation Number of Micelle: 20-40; 40
• Transition Temperature: cloud point >100 °C; cloud point ≥100 °C
• Hydrophilic Lipophilic Balance: 16; 16.9; 9.7

Safety Information

• Storage Condition: Room Temperature (15-30°C); Room Temperature (15-30°C), Desiccate
• RTECS: JR5990000; MD0875000
• European Hazard Symbols: Irritant (Xi); Harmful (Xn)
• UN Number: 3082
• German water hazard class: 1; 2
• Hazard Class: 9
• Packing Group: 3
• Risk Statements: 22-38-41; 36/37/38; 41; R:22-36/37/38
• Safety Statements: 26-36/37/39; 26-37-60; 26-39; S:25-26-36/37/39
• TSCA Listed: 是
• GHS Pictograms: GHS05; GHS07
• GHS Signal Word: Danger
• GHS Hazard statements: H302-H315-H318; H302-H315-H319-H335; H315-H318
• GHS Precautionary statements: P261-P305+P351+P338-P302+P352-P321-P405-P501A; P280-P305 + P351 + P338
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves; Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter; Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter; Eyeshields, Gloves
• RID/ADR: UN 3082 9/PG 3

Product Information

• Concentration: ~0.5% in H2O; ~10% in H2O; 0.50 % (w/w) (20°C); 10% in H2O; 30 % (w/v)
• Grade: for HPCE; for membrane research
• Suitability: in accordance for fluorescence emission; in accordance for HPCE; suitable for Stein-Moore chromatography
• Description: non-ionic
• Impurities: ≤1 ppm peroxides (as H2O2); ≤150 μM sulfhydryl oxidizing substances (carbonyls, peroxides); ≤2% water
• Cation Traces: Ca: ≤10 mg/kg; Ca: ≤50 mg/kg; Cd: ≤5 mg/kg; Cd: ≤50 mg/kg; Co: ≤5 mg/kg; Co: ≤50 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Cu: ≤50 mg/kg; Fe: ≤5 mg/kg; Fe: ≤50 mg/kg; K: ≤500 mg/kg; Mg: ≤5 mg/kg; Mg: ≤50 mg/kg; Mn: ≤5 mg/kg; Na: ≤500 mg/kg; Ni: ≤5 mg/kg; Ni: ≤50 mg/kg; Pb: ≤5 mg/kg; Pb: ≤50 mg/kg; Zn: ≤5 mg/kg; Zn: ≤50 mg/kg
• Mol. Weight: average Mn ~1,198; average mol wt 583; estimated mol wt 1198; micellar avg mol wt 48,000
• abs.: UV absorption/200-800 nm in accordance
• Linear Formula: C12H25(OCH2CH2)nOH, n~23; HO(CH2CH2O)n(CH2)11CH3

DETAILS

MP Biomedicals - 02101111

Suitable for use in Stein-Moore Chromatography.

MP Biomedicals - 02151014

Useful in solubilizing membrane proteins.

Sigma Aldrich - 88317

Legal Information
Thesit is a registered trademark of Desitin Arzneimittel GmbH

Sigma Aldrich - 16005

Other Notes
Non-ionic polyoxyethylene ether.1 Used for selective and rapid solubilization of microbial membrane aldehyde dehydrogenase.2
Legal Information
Brij is a registered trademark of Croda International PLC

Sigma Aldrich - 16012

Packaging
package with 6 x 10 ml ampoules
Legal Information
Brij is a registered trademark of Croda International PLC

Sigma Aldrich - 16001

Caution
product may precipitate on storage, resolve at 50°C
Legal Information
Brij is a registered trademark of Croda International PLC

Sigma Aldrich - 88315

Application
Suggested substitute for Lubrol in the preparation of G protein from bovine brain.1
Legal Information
Thesit is a registered trademark of Desitin Arzneimittel GmbH

Sigma Aldrich - 858366

Application
Detergent for ion-exchange chromatography.
Legal Information
Brij is a registered trademark of Uniqema Americas LLC

Sigma Aldrich - 17228

Application
Non-ionic detergents (a polyoxyethylene) for the purification, extraction and solubilization of membrane-bound proteins. Also used in storage solutions for Taq polymerase: P. Loredano et al., Biotechnol. Appl. Biochem. 30, 27 (1999)
Legal Information
Thesit is a registered trademark of Desitin Arzneimittel GmbH

Sigma Aldrich - 16013

Other Notes
Coating with Brij-35 reduces non-specific protein adsorption and lowers drastically electroosmotic pumping. This allows the pH to be varied without adversely affecting the flow rate1
Preparation Note
prepared under clean room conditions and filtered through a 0.2 μm membrane filter
Legal Information
Brij is a registered trademark of Croda International PLC

Sigma Aldrich - B4184

Application
Do you have application information on this product that you would like to share?
Legal Information
Brij is a registered trademark of Croda International PLC

Sigma Aldrich - P1254

Application
Non-ionic detergent. Useful for the extraction of membrane proteins. Typically used in the range of 0.1-1%.
Packaging
5 kg in poly bottle
500 g in poly bottle
Legal Information
Brij is a registered trademark of Uniqema Americas LLC

Sigma Aldrich - 03-3170

Suitability
amino acid analysis
Legal Information
Brij is a registered trademark of Croda International PLC

REFERENCES

• Stein, W.H. and Moore, S.J., J. Biol. Chem. , 211 : 893 (1954).
• Non-ionic surfactant. Detergent for ion chromatography. Solubilizing agent for membrane proteins.